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What are the main claims of the paper and how important are they?
To study selective usefullness of various skin extracts from fruit against melanoma cells
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Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
Yes
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Are the claims properly placed in the context of the previous literature?
Yes
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Do the results support the claims? If not, what other evidence is required?
Yes
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If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?
Yes
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Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?
Yes
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Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?
I have some suggestions-
1. This is a good study in treatment of melanoma
2. Various plant extracts are used in various disciplines of medicine in treatment of various illnesses in India for many years.
3. This study mentions about some selective benefits of theses fruit extracts in treatment of melanoma
4. We need to study its efficacy in animals & humans eventually for actual benifits in melanoma treatment.
5. The duration, side effects & cost also needs to be studied.
6. Discussion could have been more detailed.
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Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
Yes, as it opens a new dimension in treatment of melanoma
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Other Comments:
No
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
Primary malignant melanoma of anal canal. internet journal of surgery.2009
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Experience and credentials in the specific area of science:
I am working as in charge of cancer program for my institute where we study on various such experimental studies for better treatment of cancer.
- How to cite: Belekar D M.Various skin extracts from Aubergine fruit induce selective anti-cancer activity against melanoma cells[Review of the article 'Dichloroacetate, 2-Deoxyglucose and a Hydroalcoholic Extract from the Skin of the Fruit of <i>Solanum melongena</i> (Aubergine) Induce Selective Anticancer Activity against Melanoma Cells ' by Lopez-Lazaro M].WebmedCentral 2013;4(7):WMCRW002790
The main claims are the use of a hydroalcoholic extract and its anticancer activity.
They are important because it represents a new perspective in the treatment of melanoma.
Yes
Yes
Yes
The protocol provided is well placed.
Yes, the methodology is valid and can be reproduced.
As the author stands more worl should be done to improve this sublject.
Yes, specially in a world where expensive drugs are launched in a progressive way, it is very welcome this type of paper.
I would like to ask the authors to publish any results they have, even in the middle of the work, because every information about this is very important.
None
No
Yes
Fractal dimension of chromatin is an independent prognostic factor for survival in melanoma -BMC Cancer
I have an MSc and a PhD in skin cancer and I have been teaching medicine for the last 30 years