Dr. Melpomeni Peppa

Brief Biography:

Peppa Melpomeni, MD, PhD

Brief Curiculum Vitae

MAILING ADDRESS Endocrine Unit,
2nd Dept of Internal Medicine-Propaedeutic,
Research Institute and Diabetes Center, Athens University Medical School,
Attikon University Hospital 1 Rimini Str,
Haidari, Athens, Greece
E-mail address moly6592@yahoo.com. molypepa@otenet.gr
TELEPHONE (210)-5831255, (210)-5326454
DATE OF BIRTH 22/1/1965
PLACE OF BIRTH Athens,
Greece CITIZENSHIP Greece
EDUCATION M.D., 1982-1988, Aristotelion University Medical School, Thessaloniki, Greece POSTDOCTORAL

TRAINING : General practitioner,
1989-1991 : Residency Internal Medicine,
1991-1993 ¨Polykliniki¨ Hospital Internal Medicine Department, Athens,
Greece : Clinical Research-Fellowship,
1993-1995 First Pediatric Department, Athens University Medical School, ¨Aghia Sophia¨ Children´s Hospital, Athens,
Greece  Fellowship in Endocrinology,
1995-1999 Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens,
Greece : Post Doctoral Clinical Fellowship,
1999-2000, First Pediatric Department, Athens University Medical School, ¨Aghia Sophia¨ Children´s Hospital, Athens, Greece ? Post Doctoral Research Fellowship,
1999-2003 Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY ? Lecturer in Endocrinology,
2003-2011 Second Dept of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Athens, Greece ? Assist. Professor in Endocrinology,
2011-now Second Dept of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, Athens, Greece THESIS (1993-1998)

Title : “Endothelin and diabetic angiopathy. Relationship of urinary endothelin with diabetes duration, glycemic control, lipid profile, microalbuminuria, urinary free cortisol and other factors”.

PUBLICATIONS (n=48)

1. M. Peppa-Patrikiou, M. Scordili, A. Antoniou, M. Giannaki, M. Dracopoulou, C. Dacou-Voutetakis. “Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol and other factors”. Diabetes Care 1998; 21 (6): 1004-1007
2. M. Peppa-Patrikiou, M. Dracopoulou, C. Dacou-Voutetakis. “Urinary endothelin in adolescents and young adults with insulin dependent diabetes mellitus. Relation to urinary albumin, blood pressure and other factors”. Metabolism 1998; 47(11): 1408-1412
3. C. Dacou-Voutetakis, M. Peppa-Patrikiou, M. Dracopoulou. “Urinary free cortisol and its nyctohemeral variation in adolescents and young adults with IDDM: Relation to endothelin 1 and indices of diabetic angiopathy”. J Pediatr Endocrinol Metabol 1998; 11(3): 437-445
4. ?. Vaindirlis, M. Peppa-Patrikiou, M. Dracopoulou, ?. ?anoli, A. Voutetakis, C. Dacou-Voutetakis. “White coat or stress hypertension in adolescents: Increased values of urinary cortisol and endothelin”. J Pediatrics 2000; 136 (3): 359-64
5. M. Liacopoulou, ?. Alifieraki, A. Katideniou, M. Peppa, M. Maniati, D. Tzikas, E. Hibbs, C. Dacou-Voutetakis. «Maternal expressed emotion and metabolic control of children and adolescents with diabetes mellitus». Psychother Psychosom 2001; 70(2):78-85
6. H. Vlassara, W. Cai, J. Crandall, T. Goldberg, R. Oberstein, V. Dardaine, M. Peppa, E. Rayfield. Inflammatory markers are induced by dietary glycotoxins: A pathway for accelerated atherosclerosis in diabetes. Proc Natl Acad Sci 2002; 99(24):15596-601
7. WJ. Cai, QD. Cao, L. Zhu, M. Peppa, C. He, H. Vlassara. Oxidative stress-inducing carbonyl compounds from common foods: Novel mediators of cellular dysfunction. Molecular Medicine 2002; 8(7):337-46
8. M. Peppa, J. Uribarri, H. Vlassara. Advanced glycoxidation: A new risk factor for cardiovascular disease? (Review). Cardiovasc Toxicol 2002; 2 (4) :275-287
9. M. Peppa, T. Goldberg, W. Cai, E. Rayfield, H. Vlassara. Glycotoxins: A missing link in the “Relationship of dietary fat and meat intake and risk of type 2 diabetes in men”. Diabetes Care, 2002; 25 (10): 1898-9
10. J. Uribarri, M. Peppa, W. Cai, T. Goldberg, M. Lu, C. He, H. Vlassara. Restriction of dietary glycotoxins markedly reduces AGE toxins in renal failure patients. J Am Soc Nephrol, 2003; 14(3): 728-731
11. M. Peppa, C. He, M. Hattori, R. McEvoy, F. Zheng, H. Vlassara. Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice. Diabetes 2003; 52(6):1441-8
12. J. Uribarri, M. Peppa, W. Cai, T. Goldberg, S. Baliga, M. Lu, J.A.Vassalotti, H. Vlassara. Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients. Am J Kid Dis 2003; 42(3):532-8
13. M Peppa, ?. Brem, P. Ehrlich, J. Zhang, W. Cai, Z. Li, A. Croitoru, S. Thung, and H. Vlassara. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 2003; 52 (11): 2805-2813
14. M. Peppa, J. Uribarri, H. Vlassara. Glucose, advanced glycation end products (AGE) and diabetic complications. Clin Diabetes 2003, 21(4):186-188
15. M. Peppa, J. Uribarri, W. Cai, M. Lu, H. Vlassara. Glycoxidation and inflammation in renal failure patients. Am J Kid Dis 2004; 43 (4):690-696
16. T. Goldberg, W. Cai, M. Peppa, V. Dardaine, BS. Baliga, J. Uribarri, H. Vlassara. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 2004; 104(8):1287-91.
17. W. Cai, JC He, L Zhu, M. Peppa, C Lu, J. Uribarri, H. Vlassara. High Levels of Dietary Advanced Glycation End Products Transform Low-Density Lipoprotein Into a Potent Redox-Sensitive Mitogen-Activated Protein Kinase Stimulant in Diabetic Patients. Circulation. 2004;110 (3):285-291
18. G. Ioannidis, M. Peppa, P. Rontogianni, M. Callifronas, C. Papadimitriou, G. Chrysanthopoulou, L. Anthopoulos, M. Kesse, N. Thalassinos. Concurrence of microalbuminuria and retinopathy in combination with cardiovascular risk factors: reliable detection of asymptomatic coronary artery disease in type 2 diabetes. Hormones 2004; 3 (3):198-204
19. ?. Peppa, J..Uribarri, H. Vlassara. The role of advanced glycation end products in the development of atherosclerosis. (Review). Curr Diab Rep. 2004;4(1):31-6.
20. J. Uribarri, W. Cai, O. Sandu, M. Peppa, T. Goldberg, H. Vlassara. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N.Y. Acad. Sci 2005; 1043: 461-466
21. M. Peppa, H. Vlassara. Advanced glycation end products and diabetic complications. A General overview. Hormones 2005; 4 (1):28-37
22. M. Peppa, H. Brem, W.Cai, J. Basgen, L. Zhu, M. Lu, C. Lu, J. Uribarri, H. Vlassara. Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am J Nephrol 2006; 26:430-455
23. WJ. Cai, L. Zhu, H. Chen, J. Uribarri, M. Peppa. Association of advanced glycoxidation end products and inflammation markers with thrombosis of arteriovenous grafts in hemodialysis patients. Am J Nephrol 2006;26:181-185
24. J. Uribarri, WJ Cai, M. Peppa, S. Goodman, L Ferrrucci, G. Striker, H. Vlassara. Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci. 2007;62(4):427-33
25. G. Dimitriadis, I. Maratou, E. Boutati, A. Kollias, C. Tsegka, M. Alevizaki, M. Peppa, SA Raptis, D. Hatjidakis. Insulin-like growth factor 1 increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism. European Journal of Endocrinology 2008; 158(3), 361-66
26. M. Peppa, H. Boutati, S. Kamakari, V. Pikounis, G. Peros, G. Koutsodontis, V. Metaxa- Mariatou, T. Economopoulos, S. A. Raptis, D. Hadjidakis. Novel Germline Mutations of the MEN1 Gene in Greek Families with Multiple Endocrine Neoplasia Type 1. Clin Endocrinol (Oxf). 2009 ;70(1):75-81
27. K. Saltiki, A. Cimponeriu, K. Lili, M. Peppa, E. Anastasiou, M. Alevizaki. Severity of coronary artery disease in postmenopausal diabetic women. Hormones 2008; 7 (2): 148-156
28. ?. Peppa, E. Boutati, S. Kamakari, V. Pikounis, G. Peros, I. Panayiotides, T. Economopoulos, SA Raptis, D. Hadjidakis. Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene. Eur J Endocrinol. 2008 ;159(6):767-71
29. M. Peppa, SA Raptis. Advanced glycation end products and cardiovascular Disease. Current Diabetes Reviews 2008; 4 (2):92-100
30. M. Peppa, J. Uribarri, H. Vlassara. “Aging and glycoxidant stress”. Hormones 2008; 7 (2): 123-133
31. M. Peppa, P. Stavroulakis, S.A. Raptis. Advanced Glycoxidation Products and Impaired Diabetic Wound Healing (Review). Wound Rep Reg 2009; 17(4): 461–472
32. E.Maratou, D. Hadjidakis, A. Kollias, K. Tsegka, M. Peppa, M. Alevizaki, P. Mitrou, V. Lambadiari, Boutati E, D. Nikzas, N. Tountas, T. Economopoulos, SA Raptis, G. Dimitriadis. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol.2009; 160 (5):785-90
33. M. Peppa, ?. Brountzos, N. Economopoulos, E. Boutati, V. Pikounis, P. Patapis, T. Economopoulos, S. A. Raptis, D. Hadjidakis. Embolization as an alternative treatment of insulinoma in a patient with multiple endocrine neoplasia syndrome type 1. Cardiovasc Intervent Radiol. 2009 ;32(4):807-11
34. M. Peppa, I. Ekonomidis, D. Hadjidakis, V. Pikounis, J Paraskevaidis, T. Economopoulos, SA Raptis, ST Kremastinos. Dilated cardiomyopathy as the predominant feature of Cushing’s syndrome. Am J Med Sci 2009; 338(3):252-3
35. M. Peppa, G. Papaxoinis, D. Hadjidakis, N. Xiros, SA Raptis, T. Economopoulos, D. Hadjidakis. Case report: Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer. A case report and review of the literature. Clin Breast Cancer 2009; 9 (4) : E4-7
36. M. Peppa, V. Pikounis, G. Papaxoinis, A. Macheras, T. Economopoulos, S. A. Raptis, D. Hadjidakis. Adrenocortical carcinoma secreting cortisol, androgens and aldosterone: a case report. Cases Journal 2009;10(2):8951
37. M. Peppa, S. Kamakari, E. Boutati, P. Nikolopoulos, C. Giatzakis, T. Economopoulos, D. Hadjidakis, S. A. Raptis. A novel germline mutation of the VHL gene in a Greek family with Von-Hippel Lindau disease : BMJ Case Reports 2009 [doi:10.1136/bcr.02.2009.1574]
38. M. Peppa, E. Boutati, C. Koliaki, P. Nikolopoulos, N. Papaefstathiou, T. Economopoulos, D. Hadjidakis, S.A. Raptis. Insulin resistance and metabolic syndrome in patients with non-functioning adrenal incidentalomas: A cause-effect relationship? Metabolism 2010; 59(10):1435-41
39. E. Maratou, DJ. Hadjidakis, M. Peppa, M. Alevizaki, K Tsegka, V. Lambadiari, P. Mitrou, E. Boutati, A. Kollias, T. Economopoulos, SA Raptis, G. Dimitriadis. Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism. Eur J Endocrinol. 2010; 163(4):625-30
40. M. Peppa, C. Koliaki, P. Nikolopoulos, S.A. Raptis. Skeletal muscle insulin resistance in endocrine disease. J Biomed Biotechnol 2010; (doi:10.1155/2010/527850)
41. M. Peppa, C. Koliaki, S.A. Raptis. Adrenal Incidentalomas and cardiometabolic morbidity: an emerging association with serious clinical implications. J Intern Med 2010; 268 (6): 555-66
42. M. Peppa, E. Karamitopoulou, P. Nikolopoulos, G. Peros, T. Economopoulos, S. A. Raptis, D. Hadjidakis. Large adrenal oncocytoma with uncertain malignant potential. a case report and review of the literature. Endocr Pract. 2010; 16(4):641-5
43. M. Peppa, M. Dracopoulou-Vabouli, S. A. Raptis. Bilateral adrenal myelolipomas associated with 21-hydroxylase deficiency. Endocr Prac 2010; 16(3):525-6
44. P. Ferentinos, E. Rizos, A. Douzenis, A. Papadopoulou, C. Christodoulou, M. Peppa, L. Lykouras. Androgen insensitivity and liability to drug-induced extrapyramidal symptoms. Gender Medicine, 2011; 8(2): 156-60
45. M. Peppa, ?. ?rania, S.A. Raptis. Hypertension and other morbidities with Cushing’s syndrome associated with corticosteroids. A review. J Integr Blood Press Contr 2011; 4:7-16
46. M. Peppa, R. Betsi, G. Dimitriadis. Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease. J Lipids, 2011;2011:575840 (in press)
47. M. Peppa, S.A. Raptis. Glycoxidation and wound healing in Diabetes. An interesting relationship? Curr Diab Rev 2011;7(6):416-25.
48. M. Peppa, D. Vlahakos. Are we satisfied with the follow-up of hypertensive and chronic kidney disease patients in outpatient clinics? Hippokratia 2011; 15(Suppl 1):44-9.
49. E. Tsigkaropoulou, M. Peppa, C. Zompola, E. Rizos, I. Xelioti, S. Chatziioannou, A. Filippopoulou, L. Lykouras. Hypogonadism due to hyperprolactinaemia and subsequent first episode of psychosis. Gender Medicine, 2012; (in press)
50. M. Peppa, P.Nikolopoulos, P. Korkolopoulou, D. Lapatsanis, G. Dimitriadis, D. Hadjidakis, S.A Raptis. Primary MALT thyroid lymphoma: A rare thyroid neoplasm of extrathyroid origin. Journal of Rare Tumors 2012; (in press)
51. E. Trakakis, G. Basios, M. Peppa, G. Simeonidis, G. Labos, M. Creatsa, M. Misailidou, E. Boutati, V. Vaggopoulos, P. Panagopoulos, G. Dimitriades, D. Kassanos. The prevalence of glucose metabolism abnormalities in Greek women with polycystic ovary syndrome. Gynecol Endocrinol 2012 (in press) Mean Impact factor 3.5, H-index 19, Citations ISI/Scopus 1300/1553
CONFERENCES –POSTGRADUATE MEETINGS Attendant of many National and International Conferences and Scientific meetings (n=120)

AWARDS-GRANTS Awards of Hellenic Endocrinology Society, Hellenic Diabetology Society, American Diabetes Association, Hellenic Society of Internal Medicine REVIEWER OF MANUSCRIPTS-Grants I have been a refferee for 36 articles in peer-review journals and 3 International grants

AREAS OF EXPERTISE Obesity-Diabetes-Metabolism, Advanced glycation end products (AGE), Oxidative stress, Endocrine Oncology

Academic positions:

MD, PhD, Assist, Professor in Endocrinology

Research interests:

Obesity-Diabetes-Metabolism, Advanced glycation end products (AGE), Oxidative stress, Endocrine Oncology

What I think of the idea behind WebmedCentral:

This is an excellent idea