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Dr. Muhammad Aslam

Research Associate
Institute of Physiology, Justus Liebig University, Giessen, Germany
Aulweg 129
 

Brief Biography:


Muhammad Aslam, PhD
Date of Birth: 25th November 1976
Nationality: Pakistan
Marital status: Married
Institution: Institute of Physiology, Justus Liebig University, Giessen.
Address: Aulweg 129, D-35392, Giessen, Germany
Phone: 0641 49 84 637
Fax: 0641 99 47 219
E-mail: Muhammad.Aslam@Physiologie.med.uni-giessen.de
Web: http://www.uni-giessen.de/cms/fbz/fb11/institute/physiologie/personal/wis/profil-aslam/?searchterm=

Current Position:

Lecturer: Institute of Physiology, School of Medicine Justus Liebig University, Giessen, Germany
Field of Research: Molecular mechanisms (cell signalling) regulating endothelial barrier function and angiogenesis under (patho)-physiological conditions
Teaching Experience: Since 2007 – onwards Teaching physiology to the medical students at the Institute of Physiology, School of Medicine, Justus-Liebig-University, Giessen, Germany.

Publications:

Published Articles:

First, last or corresponding author:

1. Gündüz D?, Aslam M?, Krieger U, Becker L, Grebe M, Arshad M, Sedding DG, Härtel FV, Abdallah Y, Piper HM, Voss RK, & Noll T (2012). Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature. J Mol Cell Cardiol (in press)
2. Aslam M, Pfeil U, Gündüz D, Rafiq A, Kummer W, Piper HM, Noll T. Intermedin/adrenomedullin2 stabilises endothelial barrier and antagonises thrombin-induced barrier failure. Br J Pharmacol 2012 Jan;165(1):208-22.
3. Aslam M, Gündüz D, Schuler D, Li L, Sharifpanah F, Sedding D, Piper HM, Noll T. Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: Role of RhoA and Rac1. Cardiovasc Res 2011; 92:276-286.
4. Aslam M, Härtel FV, Arshad M, Gündüz D, Abdallah Y, Sauer H, Piper HM, Noll T. cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: Role of CPI-17. Cardiovasc Res 2010 March 3;87(2):375-84.
5. Gündüz D, Thom J, Hussain I, Lopez D, Härtel FV, Erdogan A, Grebe M, Sedding D, Piper HM, Tillmanns H, Noll T, Aslam M. Insulin Stabilizes Microvascular Endothelial Barrier Function via Phosphatidylinositol 3-Kinase/Akt-Mediated Rac1 Activation. Arterioscler Thromb Vasc Biol 2010 March 25;30:1237-45. Coauthor:
6. Härtel FV, Holl M, Arshad M, Aslam M, Gündüz D, Weyand M, Micoogullari M, Abdallah Y, Piper HM, Noll T. Transient hypoxia induces ERK-dependent anti-apoptotic cell survival in endothelial cells. Am J Physiol Cell Physiol 2010 March 10.
7. Pfeil U, Aslam M, Paddenberg R, Quanz K, Chang CL, Park JI, Gries B, Rafiq A, Faulhammer P, Goldenberg A, Papadakis T, Noll T, Hsu SY, Weissmann N, Kummer W. Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability. Am J Physiol Lung Cell Mol Physiol 2009 August 14;297(5):L837-L845.
8. Härtel FV, Rodewald CW, Aslam M, Gündüz D, Hafer L, Neumann J, Piper HM, Noll T. Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells. Cardiovasc Res 2007 June 1;74(3):487-96.
9. Gündüz D, Kasseckert SA, Härtel FV, Aslam M, Abdallah Y, Schäfer M, Piper HM, Noll T, Schäfer C. Accumulation of extracellular ATP protects against acute reperfusion injury in rat heart endothelial cells. Cardiovasc Res 2006 September 1;71(4):764-73.

Articles in process:

1. Aslam M, Rohrbach S, Schluter K-D, Sedding D, Piper HM, Noll T, Hamm C, and Gündüz D. Hypoxia reoxygenation-induced endothelial barrier failure: Role of RhoA, Rac1, and MLCK (Submitted)
2. Aslam M, Rohrbach S, Piper HM, Noll T, and Gündüz D. cAMP/Epac signalling stabilises endothelial barrier via PI3K/Akt independent and promotes angiogenesis via PI3K/MEK dependent manner (Submitted) 3. Wisam Iraqi, Muhammad Aslam, Tayyab Shahzad, Frauke Härtel, Jacqueline Heger, Mustafa Micoogullari, Sascha A. Kasseckert, Gerhild Euler, Thomas Noll, Hans Michael Piper, Yaser Abdallah. Inhibition of GSK-3? protects cardiomyocytes against reperfusion injury by modifying the activity of Na+/H+ exchanger (In revision).

Project Grants:

1. Faculty of Medicine (Justus-Liebig-Universität, Giessen) under the programme ‘‘Anschubfinanzierung, 2010 – 2012’’ (65,000 €)
2. Excellence Cluster cardio-pulmonary system (ECCPS) Postdoc fellowship 2008 – 2010. (70,000 €)

Academic Qualification:

Doctorate 2007 Dr. rer. nat., Justus Liebig University Thesis Titel: “Effect of cAMP/PKA signalling mechanism on barrier function of cultured endothelial cells: Role of myosin light chain phosphatase”

2004-2007 Member and scholarship holder of the DFG Research Training Group 534 “Biological Basis of Vascular Medicine’’ at the Instiute of Physiology, School of Medicine, Justus-Liebig-University Giessen Masters

2003 - M.Phil, in Molecular Biology Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan Bachelors 2000 Bachelor of Pharmacy Department of Pharmacy, University of the Punjab, Lahore, Pakistan

Awards and Fellowships:

1. Young Investigator Award from Japanese Society of microcirculation/European society of microcirculation in annual meeting 2011 in Munich.
2. Travel grant from The Physiological Society for annual Physiology meeting 2011, Oxford, UK.
3. Travel grant from FEBS for FEBS annual meeting 2011, Torino, Italy. 4. Best Poster Award in the Workshop Cardiac physiology and experimental cardiology 2010 co-organised by University of Giessen and University of Hannover, Germany.
5. Travel grant from The Physiological Society for annual Physiology meeting 2010, Manchester, UK.
6. Travel grant from FEBS for FEBS annual meeting 2010, Stockholm, Sweden.
7. Excellence cluster of cardio pulmonary system (ECCPS) postdoctoral fellowship (2008-2010)
8. Young Scientist Forum 2009: FEBS travel grant for 34th FEBS meeting in Prague.
9. Travel grant from European society of cardiology ESC annual meeting 2009 in Barcelona, Spain.
10. Young investigator award finalist from European society of cardiology (ESC) in annual meeting 2008 in Munich.
11. Travel grant from European society of cardiology ESC annual meeting 2008 in Munich, Germany.
12. Travel grant from European society of cardiology ESC annual meeting 2007 in Vienna, Austria.
13. FEBS, YTF 2006 for advanced course on microscopy/spectroscopy in Wageningen, The Netherlands.

 

Academic positions:


Research Associate/Lecturer

 

Research interests:


Molecular mechanisms (cell signalling) regulating endothelial barrier function and angiogenesis under (patho)-physiological conditions

 

Any other information:


Acts occasionally as reviewer for cardiovascular research and British journal of pharmacology

 

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