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Dr. Jinhui Wang

Brain and Cognitive Science
Institute of Biophysics, Chinese Academy of Sciences
15 Datun Road
 

Brief Biography:


Peer-reviewed journals articles (* indicates correspondent author)
1) Jin-Hui Wang and De-Pei Feng (1992). Postsynaptic protein kinase C essential to both induction and maintenance of long-term potentiation in hippocampal CA1 region. Proc. Natl. Acad. Sci. USA, 89, 2576-2580.
2) Jin-Hui Wang and Paul Kelly (1995). Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaM-KII and PKC activity. Neuron 15(2), 443-452.
3) Jin-Hui Wang and Armin Stelzer (1996). Shared calcium signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendrites. Journal of Neurophysiology. 75 (4), 1687-1701.
4) Jin-Hui Wang and Paul Kelly (1996), Regulation of synaptic facilitation by postsynaptic Ca2+ -CaM signaling pathway in rat hippocampal CA1 neurons. Journal of Neurophysiology. 76,276-286.
5) Jin-Hui Wang and Paul Kelly (1996). The balance between postsynaptic Ca2+-dependent protein kinases and phosphates controlling synaptic strength. Learning & Memory 3, 170-181 (special issue on LTP/LTD).
6) Jin-Hui Wang and Paul Kelly (1997). Postsynaptic calcineurin activity down-regulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. Journal of Neuroscience. 17, 4600-4611.
7) Jin-Hui Wang and Paul Kelly (1997). Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. Journal of Neurophysiology. 78, 2707-2716.
8) Jin-Hui Wang, G. Ko and Paul T. Kelly (1997). Cellular and molecular bases of memory: synaptic and neuronal plasticity. Journal of Clinic Neurophysiology. 14 (4), 264-293. Cited 43
9) Jin-Hui Wang* and Paul Kelly (2001). Ca2+/CaM signal pathway up-regulates glutamatergic synaptic function on non-pyramidal fast-spiking neurons in hippocampal CA1. Journal of Physiology (London) 533(2), 407-422.
10) Jin-Hui Wang* (2003). Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons in rats. Brain Research Bulletin 60 (1-2), 53-8.
11) Na Chen, Shuli Chen, Yingliang Wu, Jinhui Wang* (2006). The refractory periods and threshold potentials of sequential spikes measured by whole-cell recording. Biochemical and Biophysical Research Communications 340, 151–157.
12) Sudong Guan, Shanfeng Ma, Yan Zhu and Jin-Hui Wang* (2006). The postnatal development of refractory periods and threshold potentials at cerebellar Purkinje neurons. Brain Research, 1097, 59-64.
13) Na Chen, Yan Zhu, Xin Gao, Sudong Guan and Jin-Hui Wang* (2006). Sodium channel- mediated intrinsic mechanisms underlying the differences of spike programming among GABAergic neurons. Biochemical and Biophysical Research Communications 346, 281-287.
14) Na Chen, Xin Chen, Jiandong Yu and Jin-Hui Wang* (2006). After-hyperpolarization improves spike programming through lowering threshold potentials and refractory periods mediated by voltage-gated sodium channels. Biochemical and Biophysical Research Communications 346, 938-945.
15) Na Chen, Xin Chen and Jin-Hui Wang* (2008). Homeostasis by coordination of subcellular compartment plasticity improves spike encoding. Journal of Cell Science, 121(17):2961-2971. Cited 3
16) Jin-Hui Wang*, J. Wei, X. Chen, J. Yu, N. Chen and J. Shi (2008). The gain and fidelity of transmission patterns at cortical excitatory unitary synapses improves spike encoding. Journal of Cell Science, 121(17):2951-2960. Cited 4
17) Yu Qi, Li Huang, Hong Ni, Xin Zhou, Jing Zhang, Yan Zhu, Ming Ge, Sudong Guan and Jin-Hui Wang* (2009). Intracellular Ca2+ regulates spike encoding at cortical GABAergic neurons and cerebellar Purkinje cells differently. Biochemical and Biophysical Research Communications 381:129-133
18) Rongjing Ge, Na Chen, Jin-Hui Wang* (2009). Real-time neuronal homeostasis by coordinating VGSC intrinsic properties. Biochemical and Biophysical Research Communications 387:585-589.
19) Li Huang, Na Chen, Ming Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2010). Ca2+ and acidosis initiate the dysfunction of cortical GABAergic neurons synergistically during ischemia. Biochemical and Biophysical Research Communications 394:709-714.
20) Hong Ni, Li Huang, Na Chen, Dongbo Liu, Fengyu Zhang, Ming Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2010). Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deprivation. PLoS One 5(10):e13736.
21) Na Chen, Jiandong Yu, Hao Qian and Jin-Hui Wang* (2010). Axon amplifies somatic incomplete spikes to uniform. PLoS One 5(7):e11868.
22) Rongjing Ge, Hao Qian and Jin-Hui Wang* (2011). Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons. Molecular Brain 4,19.
23) Jiandong Yu, Hao Qian, Na Chen and Jin-Hui Wang* (2011). Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PloS One 6(9): e25219

 

Academic positions:


1) 1992--1993, postdoctoral scientist, Shanghai Institute of Biochemistry, ChineseAcademyofSciences, P. R. China. Postdoctoral fellowship award fromChineseAcademyof Sciences
2) 1993--1994, postdoctoral associate, Department of Pharmacology, State University of New York Health Science Center atBrooklyn,USA. Supported by NIH funding.
3) 1994--1999, research scientist, Department of Neurobiology and Anatomy, University of Texas Houston, USA. Supported by NIH funding.
4) 1999-2004, assistant professor (tenure-track), the Division of Biological Sciences, the University of Kansas (KU) atLawrence,Kansas,USA.
5) 2003-present, professor, theInstitute ofBiophysics,ChineseAcademy of Sciences.

 

Research interests:


Research focuses in my lab include molecular and cellular mechanisms underlying the precise analysis and computation of neural signals at the different cellular compartments (the neurons, synapses and networks), the functional development of inhibitory interneurons, as well as the genetics and neurobiology of functional disorders and ischemic stroke in the brain. Multiple disciplinary approaches are used to address these critical issues such as cellular electrophysiology with patch-clamp in vitro/vivo, cellular imaging by two-photon laser scanning microscopy in vivo, intracellular microinjection to anipulate biochemical reactions or gene expressions, gene analysis in single living neurons, lentivirus and AAV-mediated gene transfer in specific-type of neurons to knock-down or over-express genes, immunohistochemistry, behavioral tasks and math-physical modeling. Our major findings are listed in followings. 1) Homeostasis established through coordinating the function of subcellular compartments improves neuronal encoding. 2) The gain and fidelity of transmission patterns at unitary synapses improve neuronal encoding. 3) VGSC-mediated intrinsic properties navigate the spike encoding of cortical neurons. 4) An increase of intracellular Ca2+ during ischemia deteriorates the signal encoding of GABAergic neurons.

 

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