Brief Biography:
SCIENTIFIC CAREER
January 2009-present: Research Scientist in the Molecular Oncology Unit, lead by Dr. Jesus M. Paramio at CIEMAT, Madrid, Spain
February 2004 - December 2008: Senior Postdoctoral in the Epithelial Biomedicine Division lead by Dr. Jose L. Jorcano at CIEMAT, Madrid, Spain.
August 2001 - January 2004: Marie-Curie Postdoctoral Fellow in the Human Papillomavirus Group lead by Dr. Alan Storey at Cancer Research UK (CRUK), London, UK.
July 1996-July 2001: Postdoctoral fellow in the African Swine Fever Virus laboratory lead by Dr. Eladio Vinuela at Center for Molecular Biology Severo Ochoa (CBMSO)
September 1994-December 1994: Short stay in the Baculovirus Laboratory lead by Dr. Just Vlak, Wageningen Agricultural University, Wageningen, Netherlands
September 1991-June 1996: Ph.D. student at the African Swine Fever Virus laboratory lead by Dr. Eladio Vinuela at Center for Molecular Biology Severo Ochoa (CBMSO)
09/1991 – 06/1996. PhD: Inducible expression of African swine fever virus structural proteins in the laboratory of Dr. Eladio Vinuela, head of African Swine Fever Virus Group at Center for Molecular Biology Severo Ochoa (CBMSO). Grade:suma cum Laude.
1986- 1991. Master´s degree in Biology (Specialization: Biochemistry and Molecular Biology). Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Research interests:
My research interests are:
- To characterize the major molecular mechanisms and signaling pathways involved in human pathogenesis, mainly focused in the initiation, progression and metastasis of human cancer of epithelial origin.
- To determine and validate molecular biomarkers of cancer progression and metastasis, which could be used as diagnostic/prognostic tools or as targets for antitumor therapies. Special emphasis would be made in the development of genomic/genetic tests able to predict response to specific therapies, either chemotherapy regimes or targeted therapies.
These research goals would be performed using:
- Genomic high-throughput genome-wide technologies such as:
a) gene expression microarrays
b) miRNA microarrays
c) genome structure microarrays (CNV, SNP, LOH)
d) next-generation sequencing
- Analysis of different models of human cancer, such as cell lines, transgenic mice, or 3D organ systems.
- Clinical samples with patient information, including patient outcome and parameters normally used to predict outcome or to decide treatment regimens.
Any other information:
PUBLICATIONS
2011
10. Baki Akgül, Ramón García-Escudero, Christine Ekechi, Gertrud Steger, Harshad Navsaria, Herbert Pfister and Alan Storey. The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes and organotypic skin cultures. Medical Microbiology and Immunology 200(2), 127-135 , 2011.
2010
11. C Lorz, R García-Escudero, C Segrelles, MI Garín, JM. Ariza, M Santos, S Ruiz, MF. Lara, AB Martínez-Cruz, C Costa, A Buitrago-Pérez, C Saiz-Ladera, M Dueñas and JM Paramio. A Functional Role of RB-Dependent Pathway in the Control of Quiescence in Adult Epidermal Stem Cells Revealed by Genomic Profiling. Stem Cells Reviews and Reports 6, 162-177, 2010.
12. García-Escudero R, Martínez-Cruz AB, Santos M, Lorz C, Segrelles C, Garaulet G, Saiz-Ladera C, Costa C, Buitrago-Pérez A, Dueñas M, Paramio JM. Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy. Molecular Cancer 9, 193, 2010.
13. R García-Escudero and JM Paramio. Gene Expression profiling of mouse epidermal Keratinocytes. Methods Molecular Biology 585, 171-181, 2010. In Epidermal Cells. Ed K Turksen.
2009
14. M Moral, C Segrelles, AB Martínez-Cruz, C Lorz, M Santos, R García-Escudero, J Lu, A Buitrago, C Costa, C Saiz, JM Ariza, M. Dueñas, JL Rodriguez-Peralto, FJ Martinez-Tello, M Rodriguez-Pinilla, M Sanchez-Cespedes, J DiGiovanni and JM. Paramio. Transgenic mice expressing constitutive active Akt in oral epithelium validate Klf4 as a potential biomarker of head and neck squamous cell carcinoma. In Vivo 23, 653- 660, 2009.
15. A. B. Martínez-Cruz, M. Santos, R. García-Escudero, M. Moral, C. Segrelles, C. Lorz, C Saiz, A. Buitrago-Pérez, C Costa and J. M. Paramio. Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation. Anticancer research 29, 3035-3042, 2009.
16. A. Buitrago, Ana Vazquez, Guillermo Garaulet, J.M. Paramio and R. García-Escudero. Molecular signatures of HPV-induced carcinogenesis: pRb, p53 and gene expression profiling. Current Genomics 19, 26-34, 2009.
17. M Moral, C Segrelles, MF Lara, AB Martínez-Cruz, C Lorz, M Santos, R García-Escudero, J Lu, K Kiguchi, A Buitrago, C Costa, C Saiz, JL Rodriguez-Peralto, FJ Martinez-Tello, M Rodriguez-Pinilla, M Sanchez-Cespedes, M Garín, T Grande, A Bravo, J DiGiovanni and JM. Paramio. Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Research 69, 1099-1108, 2009.
2008
18. M. Santos, S. Ruiz, M. F. Lara, C. Segrelles, M. Moral, A. B. Martínez-Cruz, P. C. Lorz, R. García-Escudero and J. M. Paramio. Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage. Molecular Carcinogenesis 47, 815-821, 2008.
19. R. García-Escudero and J. M. Paramio. Gene Expression Profiling As A Tool For Basic Analysis And Clinical Application Of Human Cancer. Molecular Carcinogenesis 47, 573-579, 2008.
20. C. Segrelles, M. Moral, C. Lorz, M. Santos, J. Lu, J.L. Cascallana, M. F. Lara, S. Carbajal, A. B. Martínez-Cruz, R. García-Escudero, A. Bravo, J. DiGiovanni and J. M. Paramio. Constitutively active Akt induces ectodermal defects and impaired BMP signaling. Mol Biol Cell 19, 137-149, 2008.
21. A. B. Martínez-Cruz, M. Santos, M. F. Lara, S. Ruiz, C. Segrelles, M. Moral, C. Lorz, R. García-Escudero and J. M. Paramio. Spontaneous squamous cell carcinoma induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors in mouse stratified epithelia. Cancer Research 68, 683-692, 2008.
22. M. Fernanda Lara*, Ramón García-Escudero*, Sergio Ruiz, Mirentxu Santos, Marta Moral, Ana B. Martínez-Cruz, Carmen Segrelles, and Jesús M. Paramio. Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis. Molecular Carcinogenesis 47, 209-221, 2008. (* Author equal contribution).
23. M. Fernanda Lara, Mirentxu Santos, Sergio Ruiz, Carmen Segrelles, Marta Moral, Ana Belén Martínez-Cruz, Pilar Hernández , Jesús Martínez-Palacio, Corina Lorz, Ramón García-Escudero and Jesús M. Paramio. p107 acts as a tumor suppressor in pRb-deficient epidermis. Molecular Carcinogenesis 47, 105-113, 2008.
2007
24. C. Segrelles, J. Lu, B. Hamman, M. Santos, M. Moral, J.L. Cascallana, M. F. Lara, O. Rho, S. Carbajal, J. Traag, L Beltran, A. B. Martínez-Cruz, R. García-Escudero, C. Lorz, S. Ruiz, A. Bravo, J. M. Paramio and J Digiovanni. Deregulated activity of Akt in basal cells of stratified epithelia induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Research 67, 10879-10888, 2007.
25. Leverrier S, Bergamaschi D, Ghali L, Ola A, Warnes G, Akgul B, Blight K, Garcia-Escudero R, Penna A, Eddaoudi A, Storey A. Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Apoptosis 12(3), 549-560, 2007.
2006
26. Modesto Redrejo-Rodríguez, Ramón García-Escudero, Rafael J. Yáñez-Muñoz, María L. Salas and José Salas. African Swine Fever Virus Protein pE296R is a DNA Repair Apurinic/apyrimidinic Endonuclease Required for Virus Growth in Swine Macrophages. Journal of Virology 80, 4847-4857, 2006.
27. C Segrelles, M Moral, M Fernanda Lara, S Ruiz, M Santos, H Leis, R Garcia-Escudero, AB Martinez-Cruz, J Martinez-Palacio, P Hernandez, C Ballestin, and JM Paramio. Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 25, 1174-1185, 2006.
2005
28. Baki Akgül*, Ramón García-Escudero*, Lucy Ghali, Herbert J Pfister, Pawel G Fuchs, Harry A Navsaria, and Alan Storey. The E7 Protein of Cutaneous Human Papillomavirus Type 8 Causes Invasion of Human Keratinocytes into the Dermis In Organotypic Cultures of Skin. Cancer Research 65, 2216-2223, 2005. (* Author equal contribution).
29. B. Akgül, W. Lemme, R. García-Escudero, A .Storey and H. J. Pfister. UV-B irradiation stimulates the promoter activity of the high-risk, cutaneous human papillomavirus 5 and 8 in primary keratinocytes. Archives of Virology 150, 145-151, 2005.
2004
30. Giampieri S, Garcia-Escudero R, Green J, Storey A. Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation. Oncogene 23(24), 5864-5870, 2004.
31. Javier M. Rodríguez, Ramón García-Escudero, María L. Salas, and Germán Andrés. African swine fever virus structural protein p54 is essential for the recruitment of envelope precursors to assembly sites. Journal of Virology 78, 4299-4313, 2004.
2003
32. Ramón García-Escudero, Miguel García-Díaz, María L. Salas, Luis Blanco, and José Salas. DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA. Journal of Molecular Biology 326, 1403-1412, 2003.
33. Germán Andrés, Ramón García-Escudero, María L. Salas, and Javier M. Rodríguez. Repression of African swine fever virus polyprotein pp220-encoding gene leads to the assembly of icosahedral core-less particles. Journal of Virology 76, 2654-2666, 2003.
2001
34. Germán Andrés, Ramón García-Escudero, Eladio Viñuela, María L. Salas, and Javier M. Rodríguez. African swine fever virus structural protein pE120R is essential for virus transport from assembly sites to plasma membrane but not for infectivity. Journal of Virology 75, 6758-6768, 2001.
2000
35. Ramón García-Escudero and Eladio Viñuela. Structure of African swine fever virus late promoters: requirement of a TATA sequence at the initiation region. Journal of Virology 74, 8176-8182, 2000.
1999
36. Mariano Oliveros, Ramón García-Escudero, Ali Alejo, Eladio Viñuela, Maria L. Salas and Jose Salas. African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages. Journal of Virology 73, 8934-8943, 1999.
1998
37. German Andres, Ramón García-Escudero, Carmen Simon-Mateo and Eladio Viñuela. African swine fever virus is enveloped by a two-membraned collapsed cisterna derived from the endoplasmic reticulum. Journal of Virology 72, 8988-9001, 1998.
38. Ramón García-Escudero, German Andres, Fernando Almazan, and Eladio Viñuela. Inducible expression from African swine fever virus recombinants: analysis of the major capsid protein p72. Journal of Virology 72, 3185-3195, 1998.
1996
39. Fernando Rodriguez, Victoria Ley, Paulino Gomez-Puertas, Ramón García, Jose F Rodriguez and Jose M. Escribano. The structural protein p54 is essential for African swine fever virus viability. Virus Research 40, 161-167, 1996.
1995
40. Ramón García, Fernando Almazan, Javier M. Rodriguez, Marta Alonso, Eladio Viñuela and Jose F Rodríguez. Vectors for the genetic manipulation of African swine fever virus. Journal of Biotechnology 40, 121-131, 1995.
1994
41. Javier M Rodriguez, Fernando Almazan, Rafael J, Yanez, Ramon Garcia, Eladio Viñuela, and Jose F Rodríguez. African swine fever virus membrane-associated and secreted proteins. In: Viroceptors, virokines and related immune modulators encoded by DNA viruses. Ed. G. McFadden. Landes Company, 1994. p. 187-200. Georgetown, Texas, USA
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