Dr. Diane Harper

Brief Biography:

Diane Medved Harper, MD, MPH, MS is the Director of the Gynecologic Cancer Prevention Research Group and is a Professor of Community and Family Medicine, Biomedical and Health Informatics and Obstetrics and Gynecology at University of Missouri Kansas City School of Medicine. Her research has been well funded from a mix of federal agencies (NCI), state agencies, private foundations, and industrial partners; covering research in all aspects of cervical cancer prevention and HPV associated diseases: barriers to screening use by underserved and unserved women; leukocyte functions in the cervix; HPV detection methods by self sampling; anal cancers and EGW in MSM; quality of life assessments of screening, colposcopy and treatment methods, colposcopy improvements including frontier work in optical tissue diagnosis of CIN disease by fluorescent techniques and by acetowhitening kinetics; a member of the Steering Committee of ALTS; telecolposcopy; cost effectiveness analyses for screening and triage of cervical cancer programs; Shared Decision Making Programs for cervical cancer screening, follow up, treatment and prevention programs; and HPV vaccination work. She has received several national awards for her teaching, clinical work and research.

Academic positions:

1. 2011: Professor, Adjunct Graduate Faculty, UMKC School of Medicine
2. 2009: Vice-Chair, Research, Department of Community and Family Medicine, UMKC School of Medicine
3. 2008: Professor, Department of Community & Family Medicine, UMKC School of Medicine
4. 2008: Professor, Department of Obstetrics and Gynecology, UMKC School of Medicine
5. 2008: Professor, Department of Biomedical and Health Informatics, UMKC School of Medicine
6. 2006: Professor, Department of Women’s and Gender Studies Program, Dartmouth College
7. 2006: Professor, Department of Community and Family Medicine, Dartmouth Medical School
8. 2006: Professor, Department of Obstetrics /Gynecology, Dartmouth Medical School
9. 2003: Associate Professor, Department of Women’s and Gender Studies Program, Dartmouth College
10. 2000: Associate Professor, Department of Community and Family Medicine, Dartmouth Medical School
11. 2000: Associate Professor, Department of Obstetrics /Gynecology, Dartmouth Medical School
12. 1996: Assistant Professor, Department of Community and Family Medicine, Dartmouth Medical School
13. 1996: Assistant Professor, Department of Obstetrics /Gynecology, Dartmouth Medical School
14. 1996: Clinical Associate Professor, Department of Obstetrics /Gynecology, UMKC School of Medicine
15. 1996: Associate Professor, Department of Community and Family Medicine, UMKC School of Medicine
16. 1990: Assistant Professor, Department of Community and Family Medicine, UMKC School of Medicine
17. 1981: Research Assistant, Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA
18. 1980: Teaching Assistant, Department of Materials Science and Engineering,
Massachusetts Institute of Technology, Cambridge, MA

Awards and Honors

1. 1976: First Place Award. Chemistry Division, The International Science and Engineering Fair, for Medved DL. The Oil Sorption Capacity of Three Foams
2. 1977: London Youth International Science Fortnight, for Medved DL. The Oil Sorption Capacity of Three Foams.
3. 1978: United States National Women's Crew Team
4. 1979: Betsy Schumaker Award for the most outstanding woman athlete at Massachusetts Institute of Technology who has competed for the Massachusetts Institute of Technology and has exhibited notable athletic accomplishment beyond the collegiate competitions
5. 1980: United States Olympic Finalist for Women's Crew Team, [Olympics boycotted]
6. 1990: Most Outstanding Third-Year Family Medicine Resident Award presented for performance in Internal Medicine at Bethany Medical Center-KUMC
7. 1991: Jack L. Mulligan, MD Teacher of the Year Award, University of Missouri- Kansas City School of Medicine presented for excellence in teaching which has met the highest standards of
resident education in Family Medicine
8. 1994: Saks Fifth Avenue Leadership Recognition Award for Meritorious Community Leadership for Promotion of Early Detection of Breast Cancer. The Kansas City Leadership Summit:  The Challenge of Breast Cancer
9. 1994: ACLS Honor Roll. Recognition to the medical director and the hospital staff coordinating Advanced Cardiac Life Support Provider and Instructor classes for those hospitals whose medical, nursing and emergency room staff have maintained current ACLS training among at least 85% providers
10. 1994: Colposcopy Recognition Award, American Society of Colposcopy and Cervical Pathology
11. 1995, 1998, 2001, 2004: Physician’s Recognition Award.  American Medical Association Award
for more than 600 continuing medical education units earned in 36 months.
12. 1995: UKC Trustees’ Faculty Fellowship. $10,000 award
13. 1995: Award for Research Grant Development in Family Medicine from the North American Primary Care Research Group
14. 1988: Second Place. Housestaff Research in Medicine Symposium for Harper DM, Liese BS, Johnson CA. Symphysis-Fundus Height as a Predictor of Labor Pattern and Delivery Method. University of Kansas Medical School
15. 1988: Outstanding Research Award. Kansas Academy of Family Physicians 38th Annual Scientific Assembly for Harper DM, Liese BS, Johnson CA. Symphysis-Fundus Height as a Predictor of Labor Pattern and Delivery Method. University of Kansas Medical School
16. 1988: Second Place. Scientific Exhibits, 1988, American Academy of Family Physicians 40th Annual Scientific Assembly for Harper DM, Liese BS, Johnson CA. Symphysis-Fundus Height as a Predictor of Labor Pattern and Delivery Method. University of Kansas Medical School
17. 1990: First Place. Ciba-Geigy Resident Award, Kansas Academy of Family Physicians 40th Annual Scientific Assembly for Harper DM, Liese BS, Johnson CA, Dolezal JM, Harper WH. Cesarean Section Predicted by Parity, Age, Height, Symphysis-Fundus Height and Past Macrosomia
18. 1990: Second Place. Scientific Exhibits, American Academy of Family Physicians 42nd Annual Scientific Assembly for Harper DM, Liese BS, Johnson CA, Dolezal JM, Harper WH. Cesarean Section Predicted by Parity, Age, Height, Symphysis-Fundus Height and Past Macrosomia
19. 1990: First Place. Scientific Research Presentations, American Academy of Family Physicians 42nd Annual Scientific Assembly for Harper DM, Liese BS, Johnson CA, Dolezal JM, Harper WH. Cesarean Section Predicted by Parity, Age, Height, Symphysis-Fundus Height and Past Macrosomia
20. 1992: American Cancer Society Cancer Control Career Development Award. Provided funding for MPH Degree and Stanford training in MDM.

Research interests:

HPV associated diseases; telemedicine; shared decision making; cost effectiveness analysis; vaccinology

Any other information:

Research Publications, peer reviewed:

1. McElroy P, Medved DL, Roylance D. Weathering of Sheet Molding Compounds. In:  Environmental Degradation of Engineering Materials in Aggressive Environments. Proceedings of the Second International Conference on Environmental Degradation of Engineering Materials 473-479, September 21-23, 1981.
2. Harper DM, Walstatter BS, Lofton BJ.  Anesthetic Blocks for Loop Electrosurgical Excision Procedure.  J Fam Pract 39(3):249-256, 1994.
3. Harper DM.  Pain and Cramping Associated with Cryosurgery.  J Fam Pract 39(6):551-557, 1994.  
4. Harper, DM, Johnson CA, Harper WH, Liese BS.  Prenatal Predictors of Cesarean Section due to Labor Arrest.  Arch Gynecol Obstet 256(2):67-74, 1995.  
5. Harper DM.  The Paracervical Block Diminishes Cramping Associated with Cryosurgery.  J Fam Pract 44:71-75, 1997.
6. Comninellis NB, Harper DM.  Does Comprehensive Preventive Medicine Training Enhance Clinical Prevention?  Fam Med 29(2):112-114, 1997.
7. Ferris DG, Harper DM. The Efficacy of Topical Benzocaine Gel in Providing Anesthesia Prior to Cervical Biopsy and Endocervical Curettage.  Journal of Lower Genital Tract Disease 1(4):221-227, 1997.
8. Ferris DG, Cox JT, Burke L, Litaker MS, Harper DM, Campion MJ, Greenberg MD, Wun LM, McShane L. Colposcopy Quality Control: Establishing Colposcopy Criterion Stands for the NCI ALTS Trial. Journal of Lower Genital Tract Disease 2(4):195-203, 1998.
9. Pogue BW, Burke GC, Weaver J, Harper DM.  Multi-wavelength digital colposcopy to aid early detection of cervical cancer. Biomedical Optical Spectroscopy and Diagnostics (Vol 22) in Therapeutic Laser Applications, Trends in Optics and Photonics book series, pp. 118-21, 1998.
10. Stern JE, Givan AL, Gonzalez JL. Harper DM, White HD, Wira CR.  Leukocytes in the cervix: A Quantitative Evaluation of Cervicitis.  Obstet Gynecol 91:987-92, 1998.
11. Harper DM, Cobb JL.  Cervical Mucosal Block Effectively Reduces the Pain and Cramping from Cryosurgery.  J Fam Pract 47:285-289, 1998.
12. Tobia DM, Shamos EF, Harper DM, Walch SE, Currie JL.  The Benefits of Group Music at the 1996 Music Weekend for Women with Cancer. J Cancer Educ 14:115-119, 1999.
13. Harper DM, Cobb JL.  Is it Cost Effective to Use a Mucosal or Paracervical Block to Relieve the Pain and Cramping from Cryosurgery?  A Decision Model. J Fam Pract 48:285-290, 1999.
14. Harper DM, Hildesheim A, Cobb JL, Greenberg M, Vaught J, Lorincz A.  Collection Devices for Human Papillomavirus.  J Fam Pract 48:531-535, 1999.  
15. Pogue BW, Mycek MA, Harper DM.  Image Analysis for Discrimination of Cervical Neoplasia.  J Biomed. Optics 5(1):72-82, 2000.
16. Taylor LA, Sorensen SV, Ray NF, Halpern MT, Harper DM.  Cost effectiveness of the conventional Papanicolaou test with a new adjunct to cytological screening for squamous cell carcinoma of the uterine cervix and its precursors. Arch Fam Med 9:713-721, 2000.
17. Harper, DM, Moncur MM, Harper WH, Burke GC, Rasmussen CA, Mumford MC.  The technical performance and clinical feasibility of telecolposcopy. J Fam Pract 49:623-627, 2000.
18. Harper DM, Parke KA, Cobb JL Moncur MM.  Self-reported desire to improve colposcopic impressions.  Archives of Gynecology and Obstetrics 264:137-142, 2000.
19. Harper DM, Mayeaux EJ, Daaleman TP, Woodward LD, Ferris DG, Johnson CA. The Natural History of Cervical Cryosurgical Healing: Debridement of the Cervical Eschar has Minimal Effect. J Fam Pract 49:694-700, 2000.
20. Harper DM, Mayeaux EJ, Daaleman TP, Johnson CA.  Healing Experiences after Cervical Cryosurgery. J Fam Pract 49:701-706, 2000.
21. Pogue BW, Kaufman HB, Zelenchuk A, Harper W, Burke GC, Burke EE, Harper DM.  Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions.  J Biomed Optics 6:397-403, 2001.  
22. Harper DM, Noll WW, Belloni DR, Cole BF.  Randomized Clinical Trial of PCR Determined HPV Detection Methods:  Self-Sampling vs. Clinician-Directed -- Biological Concordance and Women’s Preferences.  Am J Obstet Gynec 186:365-373, 2002.
23. Harper DM, Noll WW, Raymond R, Duncan LT, Belloni DR, Cole BF.  Tampon samplings with longer cervico-vaginal cell exposures are equivalent to two consecutive swabs for the detection of high-risk HPV. Sexually Transmitted Diseases 29: 628-636, 2002.
24. Harper DM, Raymond M, Noll WW, Belloni DR, Cole BF.  Factors affecting the detection rate of human papillomavirus. Ann Fam Med 1: 221-7, 2003.
25. Gilbert LK, Alexander L, Grosshans J, Jolley L. [American Social Health Association. DM Harper is member of HPV Scientific Advisory Committee for ASHA conducting this study, although not a member of the writing committee, and has met the qualifications for authorship: concept design, manuscript reviews and approval of final manuscript submitted.]  Answering frequently asked questions about HPV.  Sex Trans Dis 30(3):193-4, 2003.
26. Becker HI, Longacre MR, Harper DM.  Beyond the Pap: Assessing Women’s Priorities for Annual Exams.  J Women’s Health 13:791-798, 2004.  
27. Harper DM, Schmid-Saugeon P, Zelenchuk A, Pitts JD, Kaufman HB. Kinetic Patterns of Colposcopic acetowhitening associated with cervical pathology.  Obstet Gynecol 103:18S, 2004.
28. Harper DM, Schmid-Saugeon P, Zelenchuk A, Pitts JD, Kaufman HB. Quantitative Measurements of acetowhitening may provide an adjunct to colposcopy to identify cervical intraepithelial neoplasia 2 and 3.  Obstet Gynecol 103:19S, 2004.
29. Harper DM, Huh WW, Alvarez RD, Guido RS, McIntyre-Seltman K, Schomacker KT.  The Effect of the Menstrual Cycle phases on the optical algorithms developed from diffuse reflectance.  Obstet Gynecol 103:22S, 2004.
30. Garcia F, Huh WW, Cestero RM, Gold MA, McIntyre-Seltman K, Harper DM.  Effect of age, acetic acid application method, and target distance on optical detection of CIN 2/3.  Obstet Gynecol 103:81S, 2004.
31. Huh WK, Cestero RM, Garcia FA, Gold MA, Guido RS, McIntyre-Seltman K, Harper DM, Burke L, Sum ST, Flewelling RF, Alvarez RD. Optical detection of high-grade cervical intraepithelial neoplasia in vivo: results of a 604-patient study. Am J Obstet Gynecol 190(5):1249-57, 2004.
32. Harper DM, Franco EL, Wheeler C, Ferris DG, Jenkins D, Schuind A, Zahaf T, Innis B, Naud P, Carvalho N, Rotelli C, Teixeira J, Blatter M, Korn A, Quint Wim, Dubin G for the GlaxoSmithKline HPV Vaccine Study Group.   Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial.  Lancet 364: 1757-65, 2004.
33. Villa LL, Costa RL, Petta CA, Andrade RP, Ault KA, Giuliano AR, Wheeler CM, Koutsky LA, Malm C, Lehtinen M, Skjeldestad FE, Olsson SE, Steinwall M, Brown DR, Kurman RJ, Ronnett BM, Stoler MH, Ferenczy A, Harper DM, Tamms GM, Yu J, Lupinacci L, Railkar R, Taddeo FJ, Jansen KU, Esser MT, Sings HL, Saah AJ, Barr E. Prophylactic Quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial.  Lancet Oncology. 6(5):271-8, 2005.
34. Wiley DJ, Harper DM, Elashoff D, Silverberg MJ, Kaestle C, Cook RL, Heilemann M, Johnson L. How condom use, number of receptive anal intercourse partners and history of external genital warts predict risk for external anal warts.  International Journal of STD & AIDS. 16(3):203-11, 2005.
35. Monsonego, J. [Harper DM]. EUROGIN. HPV infections and cervical cancer prevention. Priorities and new directions. Highlights of EUROGIN 2004 International Expert Meeting, Nice, France, October 21-23, 2004. Gynecologic Oncology. 96(3):830-9, 2005.
36. Harper DM, Franco EL, Wheeler C, Ferris DG, Jenkins D, Schuind A, Zahaf T, Innis B, Naud P, De Carvalho NS, Roteli-Martins CM, Teixeira J, Blatter MM, Korn AP, Quint W, Dubin G.  Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: A randomised controlled trial (vol 60, pg 171, 2005).  Obstetrical & Gynecological Survey 60(7):484-484, 2005.
37. Harper DM, Franco EL, Wheeler CM, Moscicki A-B, Romanowski B, Roteli-Martins CM, Jenkins D, Schuind A, Costa Clemens SA, Dubin G on behalf of the HPV Vaccine Study Group.  Sustained Efficacy up to 4.5 years of a bivalent L1 virus like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised controlled trial.  Lancet 2006;367:1247-55.
38. Villa LL, Ault KA, Giuliano AR, Costa RL, Petta CA, Andrade RP, Brown DR, Ferenczy A, Harper DM, Koutsky LA, Kurman RJ, Lehtinen M, Malm C, Olsson SE, Ronnett BM, Skjeldestad FE, Steinwall M, Stoler MH, Wheeler CM, Taddeo FJ, Yu J, Lupinacci L, Railkar R, Marchese R, Esser MT, Bryan J, Jansen KU, Sings HL, Tamms GM, Saah AJ, Barr E.  Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18.  Vaccine. 2006 Jul 7;24(27-28):5571-83.
39. Garland S, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, Tang GWK, Ferris DG, Steben M, Bryan J, Taddeo F, Railkar R, Esser MT, Sings HL, Nelson M, Boslego J, Sattler C, Barr E, and Koutsky LA, for the FUTURE I Investigators.  Efficacy of a quadrivalent HPV (Types 6/11/16/18) L1 VLP Vaccine against external anogenital, vaginal, and cervical disease. A randomized controlled trial.  N Engl J Medicine.  2007: 356(19):1928-43.  
40. Garland SM, Steben M, Hernandez-Avila M, Koutsky LA, Wheeler CM, Perez G, Harper DM, Leodolter S, Tang GWK, Ferris DG, Esser MT, Vuocolo SC, Nelson M, Railkar R, Sattler C, and Barr E on behalf of the 012 Study Investigators.  An evaluation of non-inferiority in antibody response to human papillomavirus (HPV) 16 in subjects vaccinated with monovalent (HPV 16) and quadrivalent (HPV 6, 11, 16, 18) L1 virus like particle vaccines.  Clinical and Vaccine Immunology. 2007 Jun;14(6):792-5.  
41. Joura EA, Leodolter S, Hernandez-Avila M, Wheeler CM,  Perez G, Koutsky LA, Garland SM, Harper DM, Tang GWK, Ferris DG,  Steben M, Jones RW, Bryan J, Taddeo FJ, Bautista OM, Esser MT, Sings HL, Nelson M, Boslego J, Sattler C, Barr E, Paavonen J.  Efficacy of a quadrivalent prophylactic human papillomavirus (types 6/11/16/18) L1 virus like particle vaccine against high-grade vulval and vaginal lesions: A combined analysis of three clinical trials.  Lancet. 2007 May 19;369(9574):1693-702.
42. Saslow D. Castle PE. Cox JT. Davey DD. Einstein MH. Ferris DG. Goldie SJ. Harper DM. Kinney W. Moscicki AB. Noller KL. Wheeler CM. Ades T. Andrews KS. Doroshenk MK. Kahn KG. Schmidt C. Shafey O. Smith RA. Partridge EE. Gynecologic Cancer Advisory Group. Garcia F. American Cancer Society Guideline for human papillomavirus (HPV) vaccine use to prevent cervical cancer and its precursors. CA: a Cancer Journal for Clinicians. 57(1):7-28, 2007 Jan-Feb.
43. Cobb KL, Bachrach LK, Sowers M, Nieves J, Greendale GA, Kent KK, Brown WB, Pettit K, Harper DM, Kelsey JL.  Randomized trial of the effect of oral contraceptives on bone mass and stress fractures in female runners.  Medicine & Science in Sports & Exercise.  2007 Sep;39(9):1464-73.
44. Cutts FT, Franceschi S, Goldie S, Castellsague X, de Sanjose S, Garnett G, Edmunds WJ, Claeys P, Goldenthal K, Harper DM, Markowitz L. Human Papillomavirus and HPV vaccines: a review. Bulletin of the World Health Organization. 2007 Sep;85(9):719-26.
45. Paavonen J, Jenkins D, Bosch FX, Naud P, Salmeron J, Wheeler CM, Chow S-N, Apter DL, Kitchener HC, Castellsague X, de Carvalho NS, Skinner SR, Harper DM, Hedrick JA, Jaisamrarn U, Limson GAM, Dionne M, Quint W, Spiessens B, Peeters P, Struyf F, Wieting SI, Lehtinen MO, Dubin G for the HPV PATRICIA study group.  Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial.  Lancet 2007;369:2161-70.   
46. Wiley DJ, Elashoff D, Masongsong EV, Harper DM, Gylys KH, Silverberg MJ,  Cook RL,  Johnson-Hill LM. Smoking enhances risk for new external genital warts in men. International Journal of Environmental Research & Public Health. 2009 Mar;6(3):1215-34.
47. Romanowski B, de Borba PC, Naud PS, Roteli-Martins CM, De Carvalho NS, Teixeira JC, Aoki F, Ramjattan B, Shier RM, Somani R, Barbier S, Blatter MM, Chambers C, Ferris D, Gall SA, Guerra FA, Harper DM, Hedrick JA, Henry DC, Korn AP, Kroll R, Moscicki AB, Rosenfeld WD, Sullivan BJ, Thoming CS, Tyring SK, Wheeler CM, Dubin G, Schuind A, Zahaf T, Greenacre M, Sgriobhadair A.  Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years.  Lancet. 2009 Dec 12;374(9706):1975-85.
48. FUTURE I/II Study Group (Harper DM), Dillner J, Kjaer SK, Wheeler CM, Sigurdsson K, Iversen OE, Hernandez-Avila M, Perez G, Brown DR, Koutsky LA, Tay EH, García P, Ault KA, Garland SM, Leodolter S, Olsson SE, Tang GW, Ferris DG, Paavonen J, Lehtinen M, Steben M, Bosch FX, Joura EA, Majewski S, Muñoz N, Myers ER, Villa LL, Taddeo FJ, Roberts C, Tadesse A, Bryan JT, Maansson R, Lu S, Vuocolo S, Hesley TM, Barr E, Haupt R. Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial. BMJ. 2010 Jul 20;341:c3493.
49. Insinga RP, Perez G, Wheeler CM, Koutsky LA, Garland SM, Leodolter S, Joura EA, Ferris DG, Steben M, Brown DR, Elbasha EH, Paavonen J, Haupt RM; FUTURE I Investigators (Harper DM).   Incidence, duration, and reappearance of type-specific cervical human papillomavirus infections in young women. Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1585-94.
50. Stoler MH, Vichnin MD, Ferenczy A, Ferris DG, Perez G, Paavonen J, Joura EA, Djursing H, Sigurdsson K, Jefferson L, Alvarez F, Sings HL, Lu S, James MK, Saah A, Haupt RM; for the FUTURE I (Harper DM), II and III Investigators. The accuracy of colposcopic biopsy: Analyses from the placebo arm of the Gardasil clinical trials. Int J Cancer 2011 Mar 15;128(6):1354-62.

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Has an interesting potential!