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Dr. Palsamy Periyasamy

Postdoctoral Research Associate
Laboratory of Molecular Biology and Aging, Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center
 

Brief Biography:


B.Sc., Biochemistry : Bharathidasan University, Tiruchirappalli, Tamilnadu, India (2001) M.Sc., Biochemistry : Bharathidasan University, Tiruchirappalli, Tamilnadu, India (2003) M.Phil., Biochemistry : Bharathidasan University, Tiruchirappalli, Tamilnadu, India (2006) Ph.D., Biochemistry : University of Madras, Chennai, Tamilnadu, India (2011) Postdoc : University of Nebraska Medical Center, Omaha, NE, USA (2010 - till date)
 

Academic positions:


2010 – Till Date : Postdoctoral Research Associate, University of Nebraska Medical Center, Omaha, NE, USA 2008 – 2010 : Awarded as Senior Research Fellow by Indian Council of Medical Research, New Delhi, India. 2006 – 2008 : Awarded as Junior Research Fellow by Indian Council of Medical Research, New Delhi, India. 2005 – 2005 : Awarded as Senior Research Fellow by Department of Biotechnology, New Delhi, India. 2004 – 2005 : Lecturer, Department of Biochemistry, Meenaakshi Ramasamy College, Ariyalur, India 2003 – 2004 : Lecturer, Department of Biochemistry, Thanthai Hans Roever College, Perambalur, India
 

Research interests:


Diabetes and its complications; Epigenetics; Phytotherapy
 

Any other information:


A. Selected Peer-reviewed Publications (in chronological order): 1. Palsamy P, Malathi R. Evaluation of hypoglycemic and hypolipidemic activity of methanolic extract of Cocculus hirsutus (L.) Diels leaves in streptozotocin-induced diabetes mellitus in rats. International Journal of Biological Chemistry. 2007;1:205-212. 2. Palsamy P, Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomedicine and Pharmacotherapy. 2008;62:598-605. 3. Palsamy P, Subramanian S. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chemico-Biological Interactions. 2009; 179:356-62. 4. Iyyam Pillai S, Palsamy P, Subramanian S, Kandaswamy M. Wound healing properties of Indian propolis studied on excision wound-induced rats. Pharmaceutical Biology. 2010;48:1198-206. 5. Sivakumar S, Palsamy P, Subramanian SP. Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats. Free Radical Research. 2010; 44:668-78. 6. Palsamy P, Subramanian S. Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress and pancreatic ?-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. Journal of Cellular Physiology. 2010; 224:423-32. 7. Sivakumar S, Palsamy P, Subramanian SP. Impact of D-pinitol on the attenuation of proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protection of kidney tissue ultrastructure in streptozotocin-induced diabetic rats. Chemico-Biological Interactions. 2010;188:237-45. 8. Palsamy P, Sivakumar S, Subramanian S. Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats. Chemico-Biological Interactions. 2010; 186:200-10. 9. Palsamy P, Subramanian S. Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2011;1812:719-31. 10. Elanchezhian R, Palsamy P, Madson CJ, Mulhern ML, Lynch DW, Troia AM, Usukura J, Shinohara T. Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells. Cell Death and Disease. 2012;3:e301. 11. Palsamy P, Ayaki M, Elanchezhian R, Shinohara T. Promoter demethylation of Keap1 gene in human diabetic cataractous lenses. Biochemical and Biophysical Research Communications. 2012; 423:542-8. 12. Mulhern ML, Madson CJ, Troia A, Elanchezhian R, Palsamy P, Shinohara T. Endoplasmic reticulum stress associated retinal photoreceptor cell death in the transgenic mutant rhodopsin S334ter-3 rats. Biomedicine and Aging Pathology. 2012;2:143-150. 13. Elanchezhian R, Palsamy P, Madson CJ, Lynch DW, Shinohara T. Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection. Chemico-Biological Interactions. 2012;200:1-10. B. Conferences Participated/Presented Presented: 1. Methylglyoxal activates chronic ER stress mediated epigenetic loss of Nrf2/Keap1 gene regulation in diabetic cataractous lenses at the ARVO 2013, Seattle, Washington, USA on 5th to 9th May 2013. 2. Epilepsy cataract: Valproic acid suppresses the Nrf2 dependent stress/antioxidant protection at the ARVO 2013, Seattle, Washington, USA on 5th to 9th May 2013. 3. Promoter demethylation of the Keap1 gene in human aging lens: A possible epigenetic mechanism for lens oxidation by failure of Keap1/Nrf2 dependent antioxidant protection at the ARVO 2012, Fort Lauderdale, Florida, USA on 5th to 9th May 2012. 4. Diabetic cataract: Endoplasmic reticulum-stress/epigenetic suppression of Nrf2-Keap1 pathway for many antioxidant enzymes at the ARVO 2011, Fort Lauderdale, Florida on 1st to 5th May 2011. 5. Impact of resveratrol on proinflammatory cytokines, polyol pathway flux enzymes and antioxidant competence in the protection of pancreatic ?-cells ultrastructure from hyperglycemia-mediated oxidative damage in streptozotocin-nicotinamide-induced diabetic rats at the “DST-sponsored National Seminar on Phytotherapeutics (NSPT - 2010)” organized by Department of Biochemistry, St. Joseph's College (Autonomous), Tiruchirappalli on 29th and 30th March 2010. 6. Hepatoprotective nature of resveratrol on ameliorating proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protecting hepatocytes’ ultrastructure in streptozotocin-nicotinamide-induced diabetic rats at the “International Conference on Advances in Free Radicals Research, Natural Products, Antioxidants and Radioprotectors in Health & Ninth Annual Meeting of The Society of Free Radical Research India” organized by Nizam’s Institute of Medical Sciences, University of Hyderabad, Hyderabad on 11th to 13th January 2010. 7. Beneficial effects of resveratrol on ameliorating diabetic dyslipidemia in streptozotocin-nicotinamide-induced experimental diabetes at the “National conference on Diabetes Mellitus and Cancer (Dia-Can’ 09)” organized by Department of Biochemistry & Biotechnology, Annamalai University, Annamalainagar on 19th and 20th December 2009. 8. Ameliorative potential of resveratrol on hyperglycemia-mediated oxidative stress and ?-cell dysfunction in streptozotocin-nicotinamide induced diabetic rats at the “International Conference on Advances in Free Radicals Research: Natural Products, Antioxidants and Radioprotectors” organized by Department of Biochemistry, Era’s Lucknow Medical College, Lucknow on 19th to 21st March 2009. 9. Beneficial antioxidative potential of resveratrol against streptozotocin-nicotinamide mediated oxidative stress in experimental diabetic rats at the “National Conference on New Frontiers and Current Trends in Biotechnology & Platinum Jubilee Celebration of Department of Biochemistry” organized by Department of Biochemistry, University of Madras, Chennai on 18th &19th October 2008. 10. Modulatory effects of resveratrol on attenuating the key enzyme activities of carbohydrate metabolism in streptozotocin-nicotinamide induced diabetic rats at the National Conference on “Medicinal and Aromatic Plants for Public Health” organized by Department of Biotechnology, Karunya University, Coimbatore, on 18th and 19th September 2008. 11. Resveratrol ameliorates streptozotocin-nicotinamide induced hyperglycemia in experimental diabetic rats at the “UGC-SAP Sponsored Workshop on Biochemical Techniques & National Conference on Natural Products in Health and Disease” organized by Department of Biochemistry & Biotechnology, Annamalai University, on 29th February to 2nd March 2008. 12. Ameliorative effects of resveratrol on oxidative damage and altered antioxidant enzyme activities in streptozotocin-nicotinamide induced diabetic rats at the “International Conference on Free Radicals & Natural Products in Health” organized by Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur on 14th to 16th February 2008. 13. Insulin-mimetic activity of resveratrol studied in STZ-induced diabetes in rats at the “XIX-Annual Conference Indian Society for Atherosclerosis Research on Recent Approaches in Atherosclerosis Research” organized by Dept. of Biochemistry, University of Madras, Chennai on 16-17th December 2006. Participated: 1. One day seminar on “Herbal Analysis and Application” held at Centre for Herbal Sciences, University of Madras, Guindy Campus, Chennai on 29th October 2008. 2. National Symposium on “Recent Trends in Molecular Diagnosis and Nanotherapeutics” organized by Department of Biochemistry, Adhiparasakthi College of Arts and Science, G.B. Nagar, Kalavai – 632 506, Vellore, Tamilnadu on 15th and 16th October 2008. 3. National Conference on “Current Trends in Algal Biodiversity and Biotechnology” organized by the CAS in Botany, University of Madras, Guindy Campus, Chennai-600 025, on 7th and 8th February, 2008. 4. Regional Symposium on “Newer Challenges in Laboratory Diagnosis for Lifestyle Diseases” organized by the PG & Research Department of Advanced Zoology & Biotechnology, and Loyola Institute of Vocational Education, Loyola College (Autonomous), Chennai-600 034, on 17th and 18th December, 2007. 5. National Conference on “Recent Trends on Medicinal Plants Research” organized by the CAS in Botany, University of Madras, Guindy Campus, Chennai 600 025, on January 24th and 25th, 2007. C. Workshop Participated: 1. Two days national workshop on “Antidiabetic Medicinal Herbs: Screening and Assessment” organized by Department of Biochemistry & Biotechnology, Annamalai University, Annamalainagar on 27th and 28th March 2009. 2. Two days workshop on “Nanostructural Materials” organized by department of Nuclear Physics, University of Madras, Guindy campus, Chennai in association with Tamilnadu Academy of Sciences, Chennai, India on 4-5th July 2008.
 

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