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Dr. Monica Fedele

Lead Researcher
Institute of Experimental Endocrinology and Oncology - National Research Counsil
via Pansini, 5
 

Brief Biography:


Monica Fedele was born in Naples, Italy, on March 23th 1969, where she graduated in Biological Sciences at the University of Naples "Federico II". Subsequently, Dr. Fedele specialized in Clinical Pathology and received her Ph.D. in Cellular and Molecular Biology and Pathology at the Medical School of the University of Naples "Federico II", Italy, working in the laboratory of Alfredo Fusco. She was a postdoctoral investigator in the laboratory of Carlo M. Croce, focusing on the development of transgenic and knockout mice for the HMGA genes. Now she is lead researcher at the Istituto di Endocrinologia e Oncologia Sperimentale (IEOS) of the National Council of the Research (CNR) in Italy and her main interest is the role of chromatinic proteins in cancer. Her main scientific achievements are the isolation and characterization of the putative tumor suppressor gene PATZ, the demonstration of the oncogenic activity of the chromatinic proteins HMGA1 and HMGA2 in vitro and in vivo, and the discovery of their critical role in the development of pituitary adenomas.

 

Academic positions:


(2010)  Eligibility as Associate Professor in General Pathology, Italy.
(2008-2011)   Adjunt Professor in "Animal Models of Human Disease", degree course in             Biotechnology for Health, Faculty of Biotechnology, University of Naples Federico II, Italy.
(2006-2007)   Adjunt Professor in "Molecular Oncology”, degree course in Medical Biotechnology,    University of Naples Federico II, Italy.

 

Research interests:


molecular bases of neoplastic transformation, HMGA proteins, genetics of pituitary adenomas, molecular mechanisms of thyroid cancer, animal models of cancer, PATZ1, CBX7, chromatinic proteins in cancer, cancer genetics.

 

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