Brief Biography:
DATE AND PLACE OF BIRTH :
July 06, 1960; Torre del Greco, Naples, Italy.
CITIZENSHIP:
Italian.
LANGUAGES:
Italian, English, French.
EDUCATION:
1978-1984: -M.D., 1st Medical School, University of Naples with Summa cum Laude. Thesis: "The role of polyamines in MSO-induced seizures".
1984-1991: -Speciality Diploma, 1st Medical School, University of Naples; Neurology Program.
1986-1990: -Ph.D. in Biochemical Sciences, 1st Medical School, University of Naples and Bari. Thesis: "Cloning, characterisation and stable expression in Balb-c 3T3 cells of the human tissue transglutaminase cDNA from endothelial cells".
Academic positions:
1980-1984: -Internship at the Department of Biochemistry and Biophysics, University of Naples.
1984-1985: -Post-Doctoral Fellow at the same institution.
1986: -Fellow at the Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Roma, Italy.
1987-1988: -Fellow at the Department of Biochemistry and Biophysics, University of Naples.
1988-1991: -Fellow at the Department of Pharmacology, University of Texas-Medical School, Houston.
1991: -Scientific consultant for Fidia Inc., Abano Terme.
1992-1993: -Visiting Assistant Professor at the Department of Pharmacology, University of Texas-Medical School at Houston.
1991-2005: -Research Assistant Professor at the Department of Biochemistry and Biophysics, II University of Naples.
2005-to date: Aggregate Professor of Biochemistry at the Department of Biochemistry and Biophysics, II University of Naples.
Research interests:
-Studies on cerebral polyamine metabolism.
-Studies on polyamine binding to synaptosomal membranes of rat brain.
-Characterisation of rat intestinal transglutaminase and studies on transglutaminase-mediated modifications of gliadins in relation to the Coeliac Disease.
-Cloning and characterisation of the gene for human tissue transglutaminase.
-Transfection of the human tissue transglutaminase cDNA in Balb-C 3T3 mouse fibroblasts: molecular and cellular characterisation of the stable transfected cell lines.
-Site direct mutagenesis of the human tissue transglutaminase cDNA.
-Characterization of the human tissue transglutaminase as a mediator of the cell signal transduction pathway.
-Studies on the possible involvement of tissue transglutaminase in pathogenesis of CAG triplet diseases.
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