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Prof. Wael El-Sayed

ElHalawany
Ain Shams University
Department of Zoology - Faculty of Science
 

Brief Biography:


Name : WAEL MOHAMED EL-SAYED
Birth date / Place : Dec 3rd, 1971 / Cairo, Egypt                                         
Marital Status : Married, 2 children.
Nationality : Egyptian.
Current Address:
Dept. of Biological Sciences - College of Science
King Faisal University
P.O. Box 380 Al-Hufof – 31982
Kingdom of Saudi Arabia
phone: +966/548021009  fax: +966/588-6437
email:   welhalawany@kfu.edu.sa
waelelhalawany@hotmail.com  

Education :

2003: Ph.D., Ain Shams University, Egypt and College of Pharmacy, University of Utah, Salt Lake City, Utah, USA under the Joint Supervision Program. Toxicology and Natural Products.
“Mechanisms of therapeutic activities of  Nigella Sativa against lipid peroxidation and hepatotoxicity in male albino rats”
1999: M.Sc., Faculty of Science, Ain shams University, Cairo, Egypt. Physiology
Effect of Nigella Sativa on some physiological and biochemical parameters in male albino rats
1993: B.Sc., Faculty of Science, Ain Shams University, Cairo, Egypt. Zoology major.

Current Position:
Associate Professor of Animal Physiology and Toxicology

Conferences:
2006, Apr The 21 st
Scientific conference of the Egyptian Society of Toxicology “Environmental factors and gene contribution”, Cairo, Egypt.
2006, Mar The 45th
Annual Meeting of the Society of Toxicology (SOT), San Diego, California-USA.
2005, Sept      
Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-USA.
2004, Sept The 22 nd
Annual Meeting of the Mountain West Society of Toxicology (MWSOT), Park City – Utah, USA.
2004, Sept      
Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-USA.
2004, Apr       
The University of Utah - College of Pharmacy Research Symposium, Salt Lake City – Utah, USA.
2002, Sept The 20 th
Annual Meeting of the Mountain West Society of Toxicology (MWSOT), Las Vegas – Nevada, USA.
2002, July The 43 rd
Annual ASP meeting (3rd Monroe Wall symposium), New Brunswick, New Jersey, USA.
2001, Aug       Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-USA.
Reviewing and Editorial Boards of Journals

Toxicology (IF 3.241) published by ElSevier/Science Direct.
Mutation Research (IF 2.552) published by ElSevier/Science Direct.
Acta Pharmacologica Sinica (IF 1.782) published by Willey.
Science Alert Journals

 

Academic positions:


2009-date: Associate Professor, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt

2004-2009: Assistant Professor, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt

2004-2006: Post Doctoral fellow, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Utah, Utah, USA.

1999-2003: Assistant lecturer, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt

1994-1999: Demonstrator, Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt

 

Research interests:


18 years experience in Physiology, Toxicology, Drug development, Molecular Biology, Natural products and Tissue Culture researches.
1. Natural products including plant and animal sources
2. Drug-drug interaction and drug metabolism
3. Evaluation of novel drugs
4. Chemoprotection and chemoprevention strategies in cancer
5. Antioxidants
6. Biochemical and molecular toxicology
7. Molecular Biology and Biotechnology

 

Any other information:


List of Publications
Published and In Press articles :
1. El-Sayed WM. Upregulation of chemoprotective enzymes by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats. International Journal of Toxicology, Accepted
2. El-SayedWM, Al-Kahtani  MA. Potential Adverse Effects of Oseltamivir in Rats: Males Are More Vulnerable Than Females. Canadian Journal of Physiology and Pharmacology, 89: 623-630, 2011. doi:10.1139/Y11-060
3. El-SayedWM, Al-Kahtani  MA, Abdul-MoneimA. Prophylactic and therapeutic potential of taurine against aluminum-induced acute hepatotoxicity in mice. Journal of Hazardous Materials, 192: 880-886, 2011. doi:10.1016/j.jhazmat.2011.05.100
4. El-Sayed WM. Effect of pregnane X receptors (PXR) prototype inducers on drug metabolizing and chemoprotective enzymes in mice. European Journal of Pharmacology, 660: 291-297, 2011. DOI: 10.1016/j.ejphar.2011.03.047
5. Ramadan G., Al-Kahtani M.A., El-Sayed W.M. Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis. Inflammation, In Press DOI: 10.1007/s10753-010-9278-0
6. El-Sayed WM, Aboul-Fadl T, Franklin MR. Effects of isatin-isoniazid derivatives on drug metabolizing and chemoprotective enzymes in mice. Drug Development Research, 71: 313-322, 2010. http://dx.doi.org/10.1002/ddr.20376
7. El-Sayed WM. Effect of three herbal extracts on mRNA levels of some drug-metabolizing enzymes in murine hepatoma cells. Egyptian Journal of Zoology,  50: 269-289, 2008.
8. Franklin MR, Moos PJ, El-Sayed WM, Aboul-Fadl T, Roberts JC. Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. Chem Biol Interact., 168(3):211-20, 2007. http://dx.doi.org/10.1016/j.cbi.2007.04.012
9. El-Sayed WM, Franklin MR. Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids. J Biochem Mol Toxicol., 20(6): 292-301, 2007. http://dx.doi.org/10.1002/jbt.20148
10. El-Sayed WM, Aboul-Fadl T, Roberts JC, Lamb JG, Franklin MR. Murine hepatoma (Hepa1c1c7) cells: A responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicology in Vitro, 21: 157–164, 2007. http://dx.doi.org/10.1016/j.tiv.2006.09.025
11. El-Sayed WM, Hussin WA, Franklin MR. The anti-mutagenicity of 2-substitiuted selenazolidine-4-(R)-carboxylic acids. Mutation Res. 627: 136-145, 2007. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805714/?tool=pubmed   
12. El-Sayed WM, Aboul-Fadl T, Lamb JG, Roberts JC, Franklin MR. Acute effects of novel selenazolidines on murine chemoprotective enzymes. Chem- Biol Interact., 162(1): 31-42, 2006. http://dx.doi.org/10.1016/j.cbi.2006.05.002
13. El-Sayed WM, Aboul-Fadl T, Lamb JG, Roberts JC, Franklin MR. Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. Toxicology, 220(2-3): 179-188, 2006. http://dx.doi.org/10.1016/j.tox.2005.12.016
14. Li L, Xie Y, El-Sayed WM, Szakacs JG, Franklin MR, Roberts JC. Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. J Biochem Mol Toxicol., 19(6): 396-405, 2005. http://dx.doi.org/10.1002/jbt.20105
15. Li L, Xie Y, El-Sayed WM, Szakacs JG, Roberts JC. Characteristics of selenazolidine prodrugs of selenocysteine: toxicity, selenium levels, and glutathione peroxidase induction in A/J mice. Life Science, 75(4): 447-459, 2004. http://dx.doi.org/10.1016/j.lfs.2003.12.018

 

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