Brief Biography:
Education
2002 Ph.D. Biochemistry (minor in Pharmacy), University of Wisconsin-Madison, Madison, Wisconsin
1992 M.S. Organic Chemistry, National Taiwan University, Taipei, Taiwan.
1990 B.S. Chemistry and Biochemistry, Tamkang University, Taipei, Taiwan.
Peer-Reviewed Publications
- Tang, K.H., Tang, Y.J. and Blankenship, R.E. (2011) Carbon metabolism pathways in phototrophic bacteria and their broader evolutionary implications. Front. Microbio. 2, 165 (Corresponding author)
- Tang, K.H., Barry, K., Chertkov, O., Dalin, E., Han, C.S., Hauser, L.J., Honchak, B.M., Karbach, L.E., Lapidus, A., Larimer, F.W., Mikhailova, N., Pitluck, S., Pierson, B.K. and Blankenship, R.E. (2011) Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. BMC Genomics. 12, 334 (Featured article)
- Tang, K.H. and Blankenship, R.E (2011) Neutron and light scattering studies of light-harvesting photosynthetic antenna complexes. Photosynth. Res. In press.
- Tang, K.H., Zhu, Y., Urban, V.S., Collins, A.M., Biswas, P. and Blankenship, R.E. (2011) Temperature and ionic strength effects on the chlorosome light-harvesting antenna complex. Langmuir 27, 4816-4828
- Tang, K.H., Feng, X., Zhuang, W.Q., Alvarez-Cohen, L., Blankenship, R.E. and Tang, Y.J. (2010) Carbon flow of heliobacteria is more related to Clostridia than to the green sulfur bacteria. J. Biol. Chem. 285, 35104-35112 (Corresponding author)
- Feng, X., Tang, K.H., Blankenship, R.E. and Tang, Y.J. (2010) Metabolic flux analysis of the mixotrophic metabolisms in the green sulfur bacterium Chlorobaculum tepidum. J. Biol. Chem. 285, 39544-39550 (Contributed equally to the work)
- Tang, K.H. and Blankenship, R.E. (2010) Both forward and reverse TCA cycles operate in the green sulfur bacteria. J. Biol. Chem. 285, 35844-35854
- Tang, K.H., Urban, V.S., Wen, J. and Blankenship, R.E. (2010) SANS investigation of the photosynthetic machinery of Chloroflexus aurantiacus. Biophys. J. 99, 2398-2407
- Tang, K.H., Yue, H, and Blankenship, R.E. (2010) Energy metabolism of Heliobacterium modesticaldum during phototrophic and chemotrophic growth. BMC Microbiology 10, 150
- Tang, K.H., Feng, X., Tang, Y.J. and Blankenship, R.E. (2009) Carbohydrate metabolism and carbon fixation in Roseobacter denitrificans OCh114. PLoS One 4, e7233
- Tang, K.H., Wen, J., Li, X. and Blankenship, R.E. (2009) Role of the AcsF protein in Chloroflexus aurantiacus. J. Bacteriol. 191, 3580-3587
- Tang, K.H., Mansoorabadi, S., Reed, G.H. and Frey, P.A. (2009) Suicide inhibition and radical triplet intermediates in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. Biochemistry 48, 8151-8160
- Maity, A., Hsieh, C.P., Huang, M.H., Chen, Y.H., Tang, K.H., Behshad, E., Frey, P.A. and Ke, S.C. (2009) Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase. J. Phys. Chem. B, 113, 12161-12163
- Tang, K.H., Niebuhr, M., Tung, C.S., Chen, S.C., Chou, C.C. and Tsai, M.D. (2008) Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways. Nucleic Acids Res. 36, 2948-2957 (Faculty of 1000) (Corresponding author)
- Tang, K.H. and Tsai, M.D. (2008) Structure and Function of 2:1 DNA polymerase-DNA complexes. J. Cell Physiol. 216, 315-320
- Tang, K.H., Niebuhr, M., Aulabaugh, A. and Tsai, M.D. (2008) Solution structures of 2:1 and 1:1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle x-ray scattering. Nucleic Acids Res. 36, 849-860
- Tang, K.H., Guo, H., Yi, W., Tsai, M.D. and Wong, G.P. (2007) Investigation of conformational states of Wzz and the Wzz•O-antigen complex under near-physiological conditions. Biochemistry 46, 11744-11752
- Showalter, A.K., Lamarche, B.J., Bakhtina, M., Su, M.I., Tang, K.H. and Tsai, M.D. (2006) Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair. Chem. Rev. 106, 340-360
- Tang, K.H., Liao, F.Y. and Tsai, Y.M. (2005) The study of intramolecular tandem radical cyclizations of acylsilanes with radicalphiles attached on silicon. Tetrahedron 61, 2037-2045
- Karbstein, K., Tang, K.H. and Herschlag, D. (2004) A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect. RNA 10, 1730-1739
- Berkovitch, F, Behshad, E., Tang, K.H., Enns, E.A., Frey, P.A. and Drennan, C.L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proc Natl Acad Sci U S A 101, 15870-15875
- Tang, K.H., Casarez, A.D., Wu, W. and Frey, P.A. (2003) Kinetic and biochemical analysis of the mechanism of action of lysine 5,6-aminomutase. Arch Biochem. Biophys. 418, 49-54
- Tang, K.H., Harms, A. and Frey, P.A. (2002) Identification of a novel pyridoxal 5´-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. Biochemistry, 41, 8767-8776
- Tang, K.H., Chang, C.H. and Frey, P.A. (2001) Electron transfer in the substrate-dependent suicide inactivation of lysine 5,6-aminomutase. Biochemistry, 40, 5190-5199
- Jiaang, W.T., Lin, H.C., Tang, K.H., Chang, L.B. and Tsai, Y.M. (1999) The study of kinetics of intramolecular radical cyclizations of acylsilanes via the intramolecular competition method. J. Org. Chem. 64, 618-628
- Chang, S.Y., Jiaang, W.T., Cherng, C.D., Tang, K.H., Huang, C.H. and Tsai, Y.M. (1997) The scope and limitations of intramolecular radical cyclizations of acylsilanes with alkyl, aryl, and vinyl radicals. J. Org. Chem. 62, 9089-9098
- Tsai, Y.M., Tang, K.H. and Jiaang, W.T. (1996) Group transfer from silicon to carbon via tandem radical cyclizations of acylsilanes. Tetrahedron Lett. 37, 7767-7770
- Tsai, Y.M., Tang, K.H. and Jiaang, W.T. (1993) Radical cyclizations of bromo acylsilanes and intramolecular trapping of the rearranged alpha-silyloxy radicals. Tetrahedron Lett. 34, 1303-1306
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