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http://www.webmedcentral.com/images/Header_Logo.giftext/html2011-08-10T20:39:05+01:00http://www.webmedcentral.com/Mr. Ram P MishraAntibacterial Properties of Anthocephalus Cadamba Fruits.
http://www.webmedcentral.com/article_view/2073
Anthocephalus cadamba is ethnomedically widely used in the form of paste by tribe in Western Ghats for treating skin diseases. In this context, antibacterial properties of Anthocephalus cadamba against a wide range of pathogens were studied. The alcoholic and aqueous extracts of fruits (ripened and un-ripened) of this plant showed significant antibacterial activity against almost all the organisms: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, with zone of inhibition of the maximum 24.0 cm and 22.0 cm against E. coli, P. aeruginosa respectively. The minimum MIC determined, was as low as 1.00 mg/ml for methanolic extracts of green fruit of A. cadamba against P. aeruginosa and S. aureus, respectively.text/html2011-08-10T20:38:12+01:00http://www.webmedcentral.com/Mr. Ram P MishraEffect of Metal Ions and Drugs on Antibacterial Activities of Nigella Sativa (L.) Seeds.
http://www.webmedcentral.com/article_view/2074
The present study was conducted to find out the antibacterial activity of aqueous and organic extracts of Nigella sativa (L.) seeds against various bacterial pathogens, namely; S. aureus, P. aeruginosa and E. coli. Plant extract along with different elicitors such as metal ions and commercial drugs was also screened to see the change in efficacy and potency of the compounds. Among different extracts ethyl acetate extract proved maximum activity towards Staphylococcus aureus and Pseudomonas aeruginosa while minimum was observed against Escherichia coli. Ethanolic and methanolic extracts exhibited dose-dependent activity. Ciprofloxacin exhibited a synergistic effect with ethyl acetate extract giving zone of inhibition of 18.0mm against S. aureus. When 0.1% Cu was mixed with Ethyl acetate extract it proved 72.0% increase in the activity as it decreased the Minimum inhibitory concentration up to 1.25mg/ml from 4.5mg/ml. No growth was found in the Nutrient agar plate which was mixed with crude oil of Nigella sativa (L.) seeds.text/html2012-08-16T20:57:47+01:00http://www.webmedcentral.com/Mr. Rajeev K SinglaEvaluation of Antibacterial Activity of Callicarpa macrophylla Vahl. Stem Extracts
http://www.webmedcentral.com/article_view/3651
Callicarpa macrophylla Vahl.(Beautyberry species) is commonly used in Indian traditional medicine. Thus an ex vivo antibacterial activity studies on ethanolic (SEE) and aqueous (SAE) stem back extracts of C. macrophylla against some gram positive and gram negative strains was done using Kirby bauer agar disc diffusion assay techniques. SEE, showed moderate growth inhibitory activity against all the bacterial strains, but SAE was exceptionally inactive against all strains except Salmonella typhimurium. The phytoconstituents in SAE might be responsible for the inhibition of S. typhimurium growth.text/html2013-01-23T19:32:27+01:00http://www.webmedcentral.com/Mr. Ram P MishraA Comparative Study and Extract Optimization for Antimicrobial Properties of Different Parts of Anthocephalus Cadamba.
http://www.webmedcentral.com/article_view/2116
Anthocephalus cadamba is ethnomedically widely used in the form of paste by tribe in Western Ghats for treating skin diseases. In this context, antibacterial properties of Anthocephalus cadamba against a wide range of pathogens were studied. The alcoholic and aqueous extracts of leaves, bark, ripened fruits and un-ripened fruits of this plant showed significant antibacterial activity against almost all the organisms: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Trichophyton rubrum, Candida albicans, Microsporum, Aspergillus niger, #MRSRA 1101 MH, #MRSRA 1102 MH, #MRSRA 1103 MH and #MRA 1001 with zone of inhibition of the maximum 24.0 mm and 22.0 mm against E. coli, P. aeruginosa respectively. The minimum MIC determined, was as low as 1.00 mg/ml for methanolic extracts of green fruit of A. cadamba against P. aeruginosa and S. aureus, respectively.Keywords: Anthocephalus cadamba, Antimicrobial properties, extract optimization, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Trichophyton rubrum, Candida albicans, Microsporum, Aspergillus niger, MRSRA 1101 MH, MRSRA 1102 MH, MRSRA 1103 MH.#MRSRA 1101 MH, MRSRA1102 MH and MRSRA1103 MH strains were provided by MRD LifeSciences, isolated in lab previously. These strains were isolated from highly contaminated soil taken from Ram Manohar Lohia Hospital, Gomti Nagar Lucknow and Vivekanand Polyclinic, Nirala Nagar Lucknow.All the three isolates possesses very high level of drug resistivity (upto 1500?g/ml) against various drug (11 drugs) and having too much inhibitory property for different bacteria (E. coli, S. aureus, P. aeruginosa) and fungi (A. niger, Microsporum, C. albicans, T. rubrum). MRSRA 1102 MH have the capability to produce bluish greenish pigmentation.#MRA 1001 is a fungal isolate in the lab and maintained at MRD LifeSciences, Lucknow. MRA 1001 has been identified a species belonging to Aspergillus niger group so far. It has capacity of growing in 1% solution of different antibiotics without any media supplement; at almost every pH range studied, temperature range from -20 0C to 100 0C and produce large amount of green spores.text/html2016-09-25T05:13:31+01:00http://www.webmedcentral.com/Dr. Deepak GuptaMythology may NOT be Just A Myth: Theoretical Biology may NOT be Just A Theory: Connecting The Dots: Was \"Sanjeevani\" Naloxone?
http://www.webmedcentral.com/article_view/5186
Steve Jobs, the co-founder of Apple Inc., once spoke that the connection among the past-dots happens in the present times, that explore the past in the retrospect. Henceforth, in the below-mentioned and elaborated text, the focus is on the possibility to explore the science underplayed when "Sanjeevani" (the reviver) was documented in the Hindu mythological epic, titled Ramayan written by sage Valmiki. It is our presumptive analysis that the sub-plot woven around "Sanjeevani" might have been to postulate the theoretical biology surrounding the catastrophic inhalational or infiltrating routes of opioids against the enemies in the ancient times and the corresponding use of inhalational or intranasal routes of antidotes to revive the victims. Who knows this was setting the grounds for future use of opioids (≈ Sammohini) under controlled conditions to induce analgesia-anesthesia and subsequent reversal of analgesia-anesthesia by naloxone (≈ Sanjeevani). Although, in recent texts, Rhodiola and Selaginella species have been suggested to come the closest to the claim as being the mythological Sanjeevani, it is our alternative postulation and interpretation that naloxone can be the elusive-enigmatic Sanjeevani as a derived component of thebaine, the extractable alkaloid of Papaver bracteatum.text/html2022-06-01T04:58:14+01:00http://www.webmedcentral.com/Dr. Deepak GuptaEternal Work-Kin-Me: Mentees Must Understand Mentors
http://www.webmedcentral.com/article_view/5779
We talk about work-kin-me as a modern-day invention in response to our modern-day workaholism induced by our modern-day consumerism and our corresponding modern-day overconsumption [1-2]. However, whether deemed workaholics or engaged with work [3-4], modern-day workers like us may have to read between the lines written in the mythological texts to realize that while choosing work over ward, we may be losing ward to work. Despite being ardent devotees of mythological Lords, it is time to understand what mythological Lords' written life-stories are telling us so as to not suffer what mythological Lords had to bear in ancient mythological lifetimes. However, there may be an alternate thought process that if ancient mythological Lords could NOT overcome what we must overcome in our modern-day lifetimes, we as modern-day mortal beings may have comparatively no control over where our workaholic or engaged with work life-histories will hopelessly culminate in the end. The lines we have to read in-between are:
• Did Lord choose His work as the King when He had to banish His pregnant Lady to forest [5]?
• Did Lord almost go to war with His twins unknowingly [6] because they were brought up by the banished Lady on Her own in the forest with genetically unrelated kin's fostering support and had questioned Lord regarding choosing job as King over kinship as Husband without knowing Lord as Father?
• Did twins forgive Lord as Father despite unanswered questions but Lady could NOT when Lady chose to finally leave for Her mother's abode [7] rather than going back with Her twins to Lord's abode and Lord could NOT override Lady's choice?
• Did caged parents of Lord lose six elder siblings of Lord to infanticidal demon caging His parents wherein ancient mythological demon inflicted infanticidal activity may be considered as metaphor/analogy for modern-day workaholism induced childhood adversity [8]?
• Did Lord's written life-story prefer work-engagement with His cousins seeking survival and justice for themselves so much that Lord lost all His own progeny including Himself [9] to the metaphorical curse by the mother who lost everyone during His cousins' work-engagement as war for survival and justice for themselves?
In a nut-shell, "me" riding on and surrendering to "work" has been becoming a bane for "kin" since ancient mythological times when "work" riding on and surrendering to "me" could have been a boon for "kin" because selfish gene [10] of "me" surviving through "kin" is competing with selfish genes of non-"me" surviving through "work" and it all boils down to who/what is at the controls in the eternal human machinery called work-kin-me.