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http://www.webmedcentral.com/images/Header_Logo.giftext/html2010-09-18T15:21:03+01:00http://www.webmedcentral.com/Dr. Bedangshu SaikiaExtreme Microcephaly, Diffuse Agyria, Agenesis of Corpus Callosum, Cerebellar Hypoplasia with Dandy-Walker Malformation: Is This A Severe Form (Barth Syndrome) or A New Variant of Microlissencephaly
http://www.webmedcentral.com/article_view/600
A five month girl with extreme microcephaly and complex brain malformation is reported. Magnetic resonance imaging (MRI) revealed bilateral thickened smooth cortex with diffuse agyria-pachygyria spectrum, agenesis of corpus callosum, bilateral hypoplastic cerebellar hemispheres and ventriculomegaly with Dandy-Walker malformation. By adding our case in the list of similar case reports by László Sztriha [1] and Mitsuhiro Kato [2], we suggest a possible classification of a new variant of microlissencephaly.text/html2010-10-04T19:23:55+01:00http://www.webmedcentral.com/Dr. Jurgen A ClaassenSafe Treatment of Hypertension to Guideline Targets in Nonagenarian Vascular Dementia
http://www.webmedcentral.com/article_view/890
More than 60 % of those over the age of 70 have hypertension, yet two-third receive no treatment or are not treated to meet current hypertension guideline criteria (≤ 140/90 mm Hg), even in case of secondary prevention [1]. Although there is evidence that blood pressure lowering in older adults effectively reduces cardiovascular risk [2], there remains concern that treatment may not confer any mortality benefit [3], whilst it could have unfavorable side-effects, including cerebral hypoperfusion. Recently, data from the HYVET study indicated that treatment of hypertension in patients aged 80 and over reduces stroke, heart failure and mortality [4]. However, trial participants were relatively healthy, and blood pressure was not rigorously lowered to meet guideline criteria.
This case study reports on the outcome of hypertensive treatment in a very old subject with cerebrovascular co-morbidity.text/html2015-01-09T13:39:35+01:00http://www.webmedcentral.com/Dr. Anuj PrabhakarCorrelation of Alberta Stroke Program Early Computed Tomography Score on CT and Volume on Diffusion Weighted MRI with National Institutes of Health Stroke Scale
http://www.webmedcentral.com/article_view/4795
Stroke is the third largest killer in the world. The disability caused by a stroke is the worst of all in majority of those who survive the acute phase. There are approximately 7,50,000 new or recurrent cases of stroke annually in United States(1). The estimated adjusted prevalence rate for stroke in India varies between 84-262/100,000 in rural to 334-424/100,000 in urban population centers. Also, based on recent population studies the incidence rate in India is approximately 119-145/100,000(2).Eighty to ninety percent of these events are ischemic strokes. This becomes all the more important in India, where 20% of strokes occur in patients of < 40 yrs of age (2). In cerebral infarction, occlusions of large vessels are responsible for 40-50% of the cases, followed by small vessel lacunar infarcts (25%). The aim of our study was to correlate the Alberta Stroke Program Early Computed tomography score (ASPECTS) and volume on diffusion weighted imaging in MRI with National Institutes of Health Stroke Scale (NIHSS). Also, we planned to analyze which variable correlated better with NIHSS. Many studies have correlated ASPECT and NIHSS and volume of infarct as seen on Diffusion Weighted Imaging (DWI) on MRI and NIHSS; however, both the parameters have not been correlated in same group patients at the same time. India is a developing country; with meager resources thus the availability of MRI is limited to big cities only. Therefore, it was planned to compare the outcome of stoke, as judged by the NIHSS scores, using both ASPECTS and infarct volume on DWI MR