Submited on: 12 Dec 2011 06:06:11 AM GMT
Published on: 12 Dec 2011 03:49:07 PM GMT
review by dr PB Verma
Posted by Prof. Jayendra R Gohil on 10 Aug 2012 09:20:05 PM GMT

Thanks for review.

 

Title of the article can be changed to "Clinical profile of Epidemic dropsy patients". Authors should concentrate only on the clinical profile of epidemic dropsy patients. -- REPLY- Preventive measures undertaken has been mentioned like the outbreak control measures used - active and passive surveillance, media campaigns, and action against traders, active case finding and treatment.

 

Type of study has not been mentioned. -- 'Retrospective' - mentioned in the title.

 

A case definition could have been included.-- Epidemic dropsy is a clinical state due to intoxication resulting from use of edible oils adulterated with the oil of Argemone mexicana (Mexican prickly poppy) seeds and is manifested as a form of pitting edema of extremities.

 

Place of estimation of HBDH and sanguinarine has not been mentioned.-- At the Industrial Toxicology centre Laboratory of ICMR at Lucknow.

There are so many references at the end, however all are not used in the text.-- There are 12 + 3 = 15 references. All are used in the text and tables.

Correction
Posted by Prof. Jayendra R Gohil on 14 Jan 2012 04:09:18 AM GMT

In the Discussion under the Biochemistry section- third sentence onwards should read as follows-

"The initial serum HBDH value (mean 165 U/l) in 33 dropsy patients was high as compared to 35 non-dropsy patients (mean 97, p<0.1). At 1-month follow-up in 17 patients, decrease in the levels was not statistically significant (mean 135 vs 128 U/l). This reflected the persisting of degenerative changes in cardiac muscles, even after stopping the consumption of adulterated oil, due to interaction of sanguinarine with cardiac glycoside receptor sites. This probably was the cause of fatigue observed, and its persistence at six months."


in place of the existing-

'The initial serum HBDH value (mean 165 U/l) in 33 dropsy patients was high as compared to 35 non-dropsy patients (mean 97, pfatigue observed, and its persistence at six months.'
The error is regretted.